Poster No:
2395
Submission Type:
Abstract Submission
Authors:
Lejla Colic1, Tara Chand1, Soroosh Golbabaei2, Larissa McClain3, Hannes Meilicke3, Luisa Herrmann4, Louise Martens4, Marina Krylova5, Igor Izyurov3, Meng Li5, Martin Walter6
Institutions:
1Jena University Hospital, Jena, AK, 2Jena University Hospital, Jena, Thuringia, 3Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany, Jena, Turingen, 4University Tübingen, Tübingen, AS, 5Jena University Hospital, Jena, Germany, 6Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Thuringia
First Author:
Co-Author(s):
Larissa McClain
Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
Jena, Turingen
Hannes Meilicke
Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
Jena, Turingen
Igor Izyurov
Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany
Jena, Turingen
Meng Li
Jena University Hospital
Jena, Germany
Martin Walter
Department of Psychiatry and Psychotherapy, Jena University Hospital
Jena, Thuringia
Introduction:
Whole brain resting state dynamics before and after acute stress task (Kühnel, 2022) may unravel alterations in brain stress response indicating maladaptive response (Hammen, 2015). Distal and proximal stress, measured as childhood adversity and recent chronic stress may modulate those dynamics (Kaiser, 2018; Söder, 2020). Moreover, other factors such as levels of excitatory neurometabolites in regions important for stress regulation, such as the pregenual anterior cingulate cortex (pgACC) (Arnsten, 2022) may further moderate these dynamics. Therefore, we investigated resting state brain dynamics and its associations with the aforementioned factors.
Methods:
Thirty-seven healthy male participants (mean age= 26.6, stan.dev= 3 years) underwent 3 Tesla (Siemens, Germany) magnetic resonance scan comprising structural T1-weighted scan, two resting-state functional magnetic resonance imaging scans (rsfMRI) before and after psychosocial scan stress task and a single-voxel magnetic resonance imaging scan in bilateral pgACC (10×20×20 mm³). RsfMRI data were preprocessed using fMRIPrep 20.1.1 (Esteban et al., 2019). Blood-oxygen-level-dependent time series of 100 regions were extracted using Schaefer-2018. Whole-brain dynamics were calculated using Kuramoto order parameter across time, i.e., "metastability" (Deco, 2017). Spectra were analyzed using LCModel (V6.3; Provencher, 2001). Signal-to-noise ratio, Cramer-Rao lower bound, and full-width-at-half-maximum were used for spectra quality checking and glutamate referenced to water signal were quantified. Participants were evaluated for childhood adversity via Childhood trauma questionnaire (CTQ-tot) and recent chronic stress via Perceived Stress Scale (PSS-tot). Outliers were detected with Rosner test. Linear-mixed models were set with stress (pre-post), CTQ-tot, PSS-tot and pgACC glutamate as fixed factors and a participant-specific random intercept (R-V4.1.3). Models tested main effect of stress on the brain dynamics and the interactions among the variables.
Results:
Glutamate significantly moderated the stress dynamics (b= 0.007, st.error= 0.003, p= .04). There were main trend effects of childhood adversity (b= -0.006, st.error= 0.003, p= .09) but no interaction effects (b= 0.0003, st.error= 0.0005, p= .4). There were no main effects of acute stress task on metastability (b= 0.006, st.error= 0.004, p= .2), nor interaction with recent chronic stress (b= 0.0008, st.error= 0.0008, p= .3).
Conclusions:
Results provide preliminary evidence for the relationship of whole-brain dynamics associations after stress and glutamate levels in a region important for stress and emotion regulation. Further, childhood adversity had a marginal man effect on the overall dynamics. Together, results point to possible mechanisms of maladaptive stress-psychopathology.
Emotion, Motivation and Social Neuroscience:
Social Neuroscience Other
Novel Imaging Acquisition Methods:
BOLD fMRI 2
MR Spectroscopy 1
Keywords:
FUNCTIONAL MRI
Glutamate
MR SPECTROSCOPY
Psychiatric
Trauma
Other - Stress
1|2Indicates the priority used for review
Provide references using author date format
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Hammen, Constance L. "Stress and depression: old questions, new approaches." Current Opinion in Psychology 4 (2015): 80-85.
Kaiser, Roselinde H., et al. "Childhood stress, grown-up brain networks: corticolimbic correlates of threat-related early life stress and adult stress response." Psychological medicine 48.7 (2018): 1157-1166.
Söder, Eveline, Katarina Krkovic, and Tania M. Lincoln. "The relevance of chronic stress for the acute stress reaction in people at elevated risk for psychosis." Psychoneuroendocrinology 119 (2020): 104684.
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