From theory to practice: Cross modal organization of the human temporal lobe
Poster No:
2132
Submission Type:
Abstract Submission
Authors:
Marius Braunsdorf1, Christian Beckmann2, James McQueen1, Rogier Mars3,1
Institutions:
1Donders Centre for Brain, Cognition and Behaviour, Nijmegen, Netherlands, 2Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, Netherlands, 3Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging; Centre, Oxford, United Kingdom
First Author:
Co-Author(s):
Christian Beckmann
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, Netherlands
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, Netherlands
Rogier Mars
Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging; Centre|Donders Centre for Brain, Cognition and Behaviour
Oxford, United Kingdom|Nijmegen, Netherlands
Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging; Centre|Donders Centre for Brain, Cognition and Behaviour
Oxford, United Kingdom|Nijmegen, Netherlands
Introduction:
The temporal lobe underwent considerable expansion and reorganization throughout the primate lineage. Mounting evidence suggests that beyond mere expansion we witness substantial differences in organization across modalities compared to other primates. An overarching theory on the functional implications of those evolutionary processes remain elusive. Recent evidence suggests at least one human unique principle of organization in the domain of function and structural connectivity. The current project aims at solidifying those principles of organization across meta-analytic computational anatomy and literature studies.
Methods:
We investigated current literature placing the temporal lobe in a primate context. We investigated several aspects of expansion and reorganization (Braunsdorf et al., 2021), as well as underlying implications spanning different modalities using Laplacian eigenmapping of meta-analytic functional activation maps. We compared those to results of temporal lobe organization in the structural connectivity domain (Braunsdorf et al., 2023).
Results:
We demonstrated a significant expansion and reorganization in the temporal lobe, exceeding mere expansion that can be expected based on total brain size. Furthermore, we showed that the 'remapping factor' (that is total area of input vs. output areas) is significantly bigger in humans compared to other species. We hypothesized two hotspots for semantic processing, one with a focus on categorization in the posterior temporal lobe, one involved in more abstract complex representations anteriorly. This general framework seems to hold across varied areas of cognition (Braunsdorf et al., 2022). We further demonstrated that functional principles of organization across a wide domain of cognitive processes resemble those found in structural connectivity (Braunsdorf, 2023; Blasquez Freches et al, 2020)
Conclusions:
Our work hypothesized an overarching theory of temporal lobe organization in a primate context. We were able to show similarities between functional and structural organization. In the future we aim to demonstrate in how far structure follows function and how individual differences in brain anatomy influence functional organization and ultimately behavioral performance in different cognitive domains.
References:
Braunsdorf, M., Freches, G. B., Roumazeilles, L., Eichert, N., Schurz, M., Uithol, S., ... & Mars, R. B. (2021). Does the temporal cortex make us human? A review of structural and functional diversity of the primate temporal lobe. Neuroscience & Biobehavioral Reviews, 131, 400-410.
Braunsdorf, M. (2023). The temporal lobe and medial wall in social cognition: Computations and organization (Doctoral dissertation, Sl: sn)
Blazquez Freches, G., Haak, K. V., Bryant, K. L., Schurz, M., Beckmann, C. F., & Mars, R. B. (2020). Principles of temporal association cortex organisation as revealed by connectivity gradients. Brain Structure and Function, 225(4), 1245-1260.
References:
Braunsdorf, M., Freches, G. B., Roumazeilles, L., Eichert, N., Schurz, M., Uithol, S., ... & Mars, R. B. (2021). Does the temporal cortex make us human? A review of structural and functional diversity of the primate temporal lobe. Neuroscience & Biobehavioral Reviews, 131, 400-410.
Braunsdorf, M. (2023). The temporal lobe and medial wall in social cognition: Computations and organization (Doctoral dissertation, Sl: sn)
Blazquez Freches, G., Haak, K. V., Bryant, K. L., Schurz, M., Beckmann, C. F., & Mars, R. B. (2020). Principles of temporal association cortex organisation as revealed by connectivity gradients. Brain Structure and Function, 225(4), 1245-1260.
Neuroanatomy, Physiology, Metabolism and Neurotransmission:
Anatomy and Functional Systems
Cortical Anatomy and Brain Mapping 1
Novel Imaging Acquisition Methods:
Anatomical MRI 2
Diffusion MRI
Keywords:
Cognition
Computational Neuroscience
Cortex
MRI
WHITE MATTER IMAGING - DTI, HARDI, DSI, ETC
Other - Temporal Lobe, Evolution
1|2Indicates the priority used for review
·Figure 1