Relationship Between Cerebrospinal Fluid Flow in the Subarachnoid Space and Beta-Amyloid Deposition
Poster No:
303
Submission Type:
Abstract Submission
Authors:
Jeongchul Kim1, Megan Lipford1, Richard Barcus2, Jeremy Hudson2, Hongyu Yuan2, Kiran Soligapram1, Qing Lyu1, Samuel Lockhart1, Suzanne Craft1, Christopher Whitlow1
Institutions:
1Wake Forest School of Medicine, Winston Salem, NC, 2Wake Forest Baptist Medical Center, Winston Salem, NC
First Author:
Co-Author(s):
Introduction:
Recent studies identified the lymphatic drainage system in the brain where cerebrospinal fluid (CSF) carries waste from brain tissue. However, it is still not well understood how CSF circulation in the brain affects waste removal. In this study, we hypothesize that CSF flow dynamics in the subarachnoid space will be correlated with beta-amyloid deposition in the brain.
Methods:
Thirteen participants (7 Cognitively Normal and 2 Mild Cognitive Impairment, Age=68±7.7 yrs. M/F=5/4) who had prior amyloid PET imaging were recruited for CSF flow MRI from the Wake Forest Alzheimer's Disease Research Center. The CSF flow patterns during the cardiac cycle were measured using the phase-contrast MRI at the cerebral aqueduct, pontine cistern and cerebellomedullary cistern (Figure 1). Images were acquired for 40 cardiac cycles with a pulse oximeter and CSF flow profiles were estimated using the retrospective cardiac gating method. PET Amyloid burden in the whole gray matter (GM) was measured as the standardized update value ratio (SUVR, cerebellar gray matter as a reference region) from the prior PET imaging and corresponding MRI.
·Regions of interest (left) for PC-MRI and CSF flow profiles during the cardiac cycle (right).
Results:
CSF flow amplitude normalized by the intracranial volume (ICV) demonstrated moderate to strong correlations with beta-Amyloid SUVR in GM (Figure. 2); Pearson's correlation coefficient (rho) was -0.59 (p=0.036) and -0.84 (p=0.004) at pontine cistern and cerebellomedullary cistern, respectively. The lateral ventricle volume normalized by ICV was also moderately correlated with GM SUVR (rho=0.495).
·Correlations between CSF flow and beta-Amyloid deposition.
Conclusions:
At an early stage of AD, the CSF circulation in the subarachnoid space could be correlated with beta-Amyloid deposition. Therefore, CSF flow in the subarachnoid space could be a useful imaging marker to predict the clearance of beta-amyloid in the brain.
Disorders of the Nervous System:
Neurodegenerative/ Late Life (eg. Parkinson’s, Alzheimer’s) 1
Modeling and Analysis Methods:
Methods Development
PET Modeling and Analysis
Neuroanatomy, Physiology, Metabolism and Neurotransmission:
Neuroanatomy Other
Novel Imaging Acquisition Methods:
Multi-Modal Imaging 2
Keywords:
Aging
Cerebro Spinal Fluid (CSF)
MRI
Positron Emission Tomography (PET)
1|2Indicates the priority used for review
Provide references using author date format
Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med. 2012;4(147):147ra11.