Poster No:
663
Submission Type:
Abstract Submission
Authors:
Euisun Kim1,2, Jiyoung Park3,2, Yelim Lee1,2, Maengkeun Oh2, Sole Yoo3,2, WooYong Lee1,2, Jiho Min4,2, Hae-Jeong Park2,5,1,3
Institutions:
1Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea, Republic of, 2Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Cognitive Science, Yonsei University, Seoul, Korea, Republic of, 4Kyung Hee University, Seoul, Korea, Republic of, 5Center for Systems and Translational Brain Sciences, Institute of Human Complexity and Systems Scien, Seoul, Korea, Republic of
First Author:
Euisun Kim
Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Co-Author(s):
Jiyoung Park
Department of Cognitive Science, Yonsei University|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Yelim Lee
Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Maengkeun Oh
Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of
Sole Yoo
Department of Cognitive Science, Yonsei University|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
WooYong Lee
Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Jiho Min
Kyung Hee University|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Hae-Jeong Park
Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine|Center for Systems and Translational Brain Sciences, Institute of Human Complexity and Systems Scien|Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine|Department of Cognitive Science, Yonsei University
Seoul, Korea, Republic of|Seoul, Korea, Republic of|Seoul, Korea, Republic of|Seoul, Korea, Republic of
Introduction:
The insula, classically associated with interoception, plays a crucial role beyond bodily awareness. Malfunctions in interoceptive processes, notably in anxiety disorders, distorts emotional experiences. This intricate relationship between insula function and emotional well-being emphasizes the necessity for thorough neural exploration. While existing research has primarily concentrated on the insula as a whole, we take a novel approach by examining the subdivisions of the insula-specifically, the ventral anterior insula (vAI), dorsal anterior insula (dAI), and posterior insula (PI). This exploration is grounded in recent findings indicating diverse structural and functional characteristics among these subdivisions. We hypothesize that, due to their distinct functional roles, the three insula subdivisions may exhibit different functional connectivity patterns in both generalized anxiety disorder (GAD) and social anxiety disorder (SAD) patients when compared to their healthy counterparts. By using the Healthy Brain Network (HBN) Biobank Data (Release 10.0) and the Adolescent Brain and Cognitive Development (ABCD) study data (Release 4.0), our objective is to contribute to a deeper understanding of the neural underpinnings of anxiety disorders.
Methods:
We use resting-state functional magnetic resonance(rsfMRI) imaging data of 76 children with GAD, 37 children with SAD and 106 healthy children from the HBN Biobank and ABCD data. The age of the children included in our dataset was from 9 to 12 years old. To explore the functional connectivity patterns of the insula subdivisions, we performed Seed-to-Voxel analyses for the bilateral ventral anterior insula (vAI), the dorsal anterior insula (dAI), and the posterior insula (PI) across the three groups. Age and sex of participants in each group were controlled for as covariates. We conducted conventional preprocessing steps using SPM12 and analyzed seed-to-voxel functional connectivity and graph analysis using the CONN toolbox (version 21.a).
Results:
Individuals with GAD showed the increased functional connectivity between the right posterior insula (rPI) and the left temporal superior lobules, suggesting heightened engagement in sensory and cognitive processes. Additionally, enhanced rPI connectivity with the right Rolandic operculum, known as the sensory system for gustatory and visceral sensation, pointed to potential involvement in altered sensory perception in GAD patients. The left ventral anterior insula (lvAI) in GAD patients displayed heightened connectivity with the right hippocampus, implicated in interoceptive processing, while connectivity with the right middle temporal gyrus, involved in multimodal sensory integration, decreased. Additionally, GAD patients showed increased connectivity between the left posterior insula (lPI) and the left inferior frontal gyrus, associated with language processing. In SAD patients, the right dorsal anterior insula (rdAI) exhibited heightened connectivity with the right precuneus, linked to emotional state evaluation. The left dorsal anterior insula (ldAI) in SAD patients demonstrated increased connectivity with the left precentral gyrus, associated with motor function. When comparing GAD and SAD, GAD patients displayed heightened connectivity between lvAI and regions related to gustatory and visceral sensation, along with decreased connectivity with the left cerebellum.
Conclusions:
Our investigation of insula subdivisions in pediatric anxiety disorders revealed distinctive functional connectivity patterns. GAD patients exhibited heightened connectivity between the right posterior insula and sensory-cognitive regions, indicating increased engagement. In contrast, SAD patients displayed connectivity changes in emotion and motor-related areas. This study underscores the significance of investigating insula subdivisions, providing valuable insights into the nuanced neural underpinnings of anxiety.
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Emotion, Motivation and Social Neuroscience:
Emotion and Motivation Other
Lifespan Development:
Early life, Adolescence, Aging
Modeling and Analysis Methods:
Connectivity (eg. functional, effective, structural) 2
Keywords:
Anxiety
FUNCTIONAL MRI
Other - Insula Subdivisions, HBN Biobank, ABCD study
1|2Indicates the priority used for review
Provide references using author date format
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