Poster No:
656
Submission Type:
Abstract Submission
Authors:
Vasco Diogo1,2, Diana Prata3,4
Institutions:
1CIS-Iscte, Iscte-Instituto Universitário de Lisboa, Lisboa, Lisboa, 2Instituto de Biofísica e Engenharia Biomédica - Faculdade de Ciências da Universidade de Lisboa, Lisboa, Portugal, 3Instituto de Biofísica e Engenharia Biomédica - Faculdade de Ciências da Universidade de Lisboa, Lisboa, Lisboa, 4Institute of Psychiatry, Psychology & Neuroscience King's College London, London, United Kingdom
First Author:
Vasco Diogo
CIS-Iscte, Iscte-Instituto Universitário de Lisboa|Instituto de Biofísica e Engenharia Biomédica - Faculdade de Ciências da Universidade de Lisboa
Lisboa, Lisboa|Lisboa, Portugal
Co-Author:
Diana Prata
Instituto de Biofísica e Engenharia Biomédica - Faculdade de Ciências da Universidade de Lisboa|Institute of Psychiatry, Psychology & Neuroscience King's College London
Lisboa, Lisboa|London, United Kingdom
Introduction:
Psychotic disorders are characterized by deficits in social cognition, for which there are limited effective treatments. Oxytocin (OT), a neuropeptide involved in social cognition, has shown potential for clinical benefits in patients with psychotic disorders. Our recent study aimed to explore the effects of intranasal OT administration on the brain activity in patients with psychotic disorders during a naturalistic social cognition task.
Methods:
Using functional magnetic resonance imaging (fMRI), we investigated the brain activity of 37 men with psychotic disorders randomly assigned to receive intranasal OT or a placebo, while 20 healthy men received a placebo (PBO). Participants viewed 16 40-second long video clips during the imaging session. Region of interest were defined using the AAL 2 parcellation and the Yeo 7 network parcellation. Data was analyzed using inter-subject correlation (ISC) within a Bayesian multilevel framework. (Chen et. al, 2020) ISC was calculated between each pair of subjects belonging to the same group (within-group ISC) and compared across groups.
Results:
Emotional videos elicited ISC in Visual and Dorsal Attention Networks in each and every group. Results demonstrated that patients who received the placebo showed decreased ISC in the Dorsal Attention and Visual networks compared to healthy controls. In contrast, patients who received OT did not show significant ISC differences compared to controls.
Regarding AAL2 brain regions, patients receiving placebo showed decreased ISC in 28 regions and increased ISC in 7 regions when compared with healthy controls. The largest effect was observed in the left inferior occipital gyrus (z-score=-0.20, meaning HC were more synchronized than patients) Meanwhile, patients receiving OT showed decreased ISC in only 13 regions, and decreased ISC in 12 regions, with the largest estimate (z-score), being -0.09 ,in the right middle occipital gyrus.
Conclusions:
These findings suggest that intranasal OT administration can normalize the inter-subject correlation of brain activity in patients with psychotic disorders across resting state networks. These findings also confirm that ISC is altered in patients with psychosis, with ISC being lower or higher in patients depending on the brain region. Intranasal OT administration is shown to normalize these alterations across multiple brain regions, decreasing or increasing ISC depending on the disfunction, and never exacerbating it. Sharing these findings is crucial as it provides insights into the neurobiological mechanisms underlying social cognition deficits in psychotic disorders and highlights the potential of OT as a therapeutic intervention for enhancing social cognition. These findings contribute to the development of more effective treatment strategies and improving the quality of life for individuals with psychotic disorders.
This work was supported by: FCT UIDB/00645/2020 (doi:10.54499/UIDB/00645/2020) and UIDB/03125/2020 (doi:10.54499/UIDB/03125/2020)
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Emotion, Motivation and Social Neuroscience:
Emotional Perception
Modeling and Analysis Methods:
Bayesian Modeling
Novel Imaging Acquisition Methods:
BOLD fMRI
Physiology, Metabolism and Neurotransmission :
Pharmacology and Neurotransmission 2
Keywords:
DISORDERS
FUNCTIONAL MRI
Psychiatric Disorders
Other - oxytocin
1|2Indicates the priority used for review
Provide references using author date format
Gang C. (2020), 'Untangling the relatedness among correlations, part III: Inter-subject correlation analysis through Bayesian multilevel modeling for naturalistic scanning', NeuroImage, vol. 216, 116474