Poster No:
653
Submission Type:
Abstract Submission
Authors:
Jiyoung Park1,2, Euisun Kim3,2, Maengkeun Oh2, Yelim Lee3,2, Sole Yoo1,2, Jiho Min4,2, WooYong Lee3,2, Hae-Jeong Park2,1,3,5
Institutions:
1Department of Cognitive Science, Yonsei University, Seoul, Korea, Republic of, 2Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4College of Humanities, Kyunghee University, Seoul, Republic of Korea, Seoul, Korea, Republic of, 5Center for Systems and Translational Brain Sciences, Institute of Human Complexity and Systems Science, Yonsei University, Seoul, Korea, Republic of
First Author:
Jiyoung Park
Department of Cognitive Science, Yonsei University|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Co-Author(s):
Euisun Kim
Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Maengkeun Oh
Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of
Yelim Lee
Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Sole Yoo
Department of Cognitive Science, Yonsei University|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Jiho Min
College of Humanities, Kyunghee University, Seoul, Republic of Korea|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
WooYong Lee
Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine|Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Hae-Jeong Park
Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine|Department of Cognitive Science, Yonsei University|Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine|Center for Systems and Translational Brain Sciences, Institute of Human Complexity and Systems Science, Yonsei University
Seoul, Korea, Republic of|Seoul, Korea, Republic of|Seoul, Korea, Republic of|Seoul, Korea, Republic of
Introduction:
The insula integrates bottom-up and top-down information in emotional and cognitive processing, with networks centered on the anterior insula contributing to the integration of descending and ascending information in these processes. Additionally, the ventral and dorsal anterior insula are associated with interoceptive self-awareness, and cognitive processing, while the posterior insula is known for processing interoceptive and exteroceptive sensations or sensory information. Each of these insula regions is implicated in the dysfunction of emotion regulation and interoceptive self-awareness in depression. However, specific functional abnormalities in the insula related to depression remain less elucidated. Therefore, this study aims to systematically investigate the functional connectivity of subregions of the insula, namely the dorsal anterior area (dAI), ventral anterior area (vAI), and posterior insula (PI), with other regions of the brain in children with depression.
Methods:
The current study utilized data sourced from the Healthy Brain Network biobank (HBN) Study (ver.10.0 release) and the Adolescent Brain and Cognitive Development (ABCD) Study (ver. 4.0 release). The participants included 55 individuals diagnosed with Major Depressive Disorder (MDD), 15 with Persistent Depressive Disorder (PDD), and 70 healthy controls. Children aged 9 to 13 years were recruited from throughout the United States.
The resting-state functional magnetic resonance imaging (rsfMRI) data underwent preprocessing with SPM12 and analysis using the CONN functional connectivity toolbox (Version 21a). A seed-based approach was employed to detect distinct functional connectivity patterns involving the three subregions of the insula in children with MDD and PDD. The region of interest (ROI) masks was selected: the left ventral anterior insula (-33, 13, -7), the right ventral anterior insula (32, 10 -6), the left dorsal anterior insula (-38, 6, 2), the right dorsal anterior insula (35, 7, 3), the left posterior insula (-38, -6, 5), the right posterior insula (35, -11, 6).
Results:
Children with MDD exhibited heightened connectivity between the left vAI and the lateral occipital cortex compared to the control group, along with elevated connectivity between the right dAI and the cerebellum. Additionally, increased connectivity was observed between the left dAI and the precuneous cortex, cingulate gyrus, and cerebellum, while showing diminished connectivity with the brain stem. In the case of children with PDD, heightened connectivity was observed between the left vAI and the precuneous cortex, cingulate gyrus compared to the control group. Furthermore, increased connectivity was noted between the left PI and the angular gyrus, supramarginal gyrus in the PDD group.
Conclusions:
Through this study, we observe enhanced neural connectivity in specific brain regions across MDD and PDD, previously distinguished by different diagnoses. Firstly, the left vAI, known to be associated with emotional processing, and the precuneus cortex, linked to self-referential thinking, exhibited heightened connectivity. Such elevated connectivity between these brain regions may be related to the specific symptoms of self-focused thinking and emotions observed in both MDD and PDD. Additionally, the heightened connectivity between left dAI and cerebellum in MDD children suggests difficulties in emotional regulation. On the other hand, the low connectivity between left dAI and brain stem implies challenges in physiological regulation, particularly in interactions with the autonomic nervous system. This may indicate difficulties in self-awareness and emotional processing in the context of MDD. These findings contribute to a deeper understanding of the neurobiological underpinnings of depression in the pediatric population indicating specific alterations in insula connectivity may play a significant role in the manifestation of depressive symptoms during childhood.
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Emotion, Motivation and Social Neuroscience:
Emotional Perception
Self Processes
Higher Cognitive Functions:
Executive Function, Cognitive Control and Decision Making
Modeling and Analysis Methods:
fMRI Connectivity and Network Modeling 2
Keywords:
Data analysis
FUNCTIONAL MRI
Other - Insula subdivision, Dorsal anterior region, Ventral anterior region, Posterior insula, Children Major depressive disorder, Children persistent depressive disorder, Functional connectivity
1|2Indicates the priority used for review
Provide references using author date format
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