Poster No:
2429
Submission Type:
Abstract Submission
Authors:
Hyeon Jin Kim1,2, Hyunsan Cho3,2, Sunhae Lee1, Seong-Jin Son4
Institutions:
1Department of Neurology, Korea University Ansan Hospital, Ansan-si, Korea, Republic of, 2Institute of Human Genomic Study, Korea University, College of Medicine, Seoul, Korea, Republic of, 3BK 21 Four R&E Center for Learning Health Systems, Korea University, Seoul, Korea, Republic of, 4Core Research & Development Center, Korea University Ansan Hospital, Ansan-si, Korea, Republic of
First Author:
Hyeon Jin Kim, MD
Department of Neurology, Korea University Ansan Hospital|Institute of Human Genomic Study, Korea University, College of Medicine
Ansan-si, Korea, Republic of|Seoul, Korea, Republic of
Co-Author(s):
Hyunsan Cho, PhD
BK 21 Four R&E Center for Learning Health Systems, Korea University|Institute of Human Genomic Study, Korea University, College of Medicine
Seoul, Korea, Republic of|Seoul, Korea, Republic of
Sunhae Lee
Department of Neurology, Korea University Ansan Hospital
Ansan-si, Korea, Republic of
Seong-Jin Son, PhD
Core Research & Development Center, Korea University Ansan Hospital
Ansan-si, Korea, Republic of
Introduction:
Globally, suicide comprises 3% of mortality, with South Korea having the highest rate (24.6 per 100,000 persons) among OECD countries. The prefrontal cortex (PFC) is crucial for understanding the neurobiological basis of suicidal ideation, yet inconclusive findings persist due to limited samples. Korea's baby boomers born between 1955 and 1963 represents a unique generation that encountered numerous either societal or personal traumatic experience throughout their lifetime, and the prevalence of suicidal thoughts within this demographic represents a critical mental health concern. The present study aims to measure and analyze the hemodynamic responses in the PFC using functional Near-Infrared Spectroscopy (fNIRS) in Korean Baby Boomers, specifically focusing on individuals with a history of previous suicidal ideation.
Methods:
About 360 participants completed the comprehensive questionnaire investigating various trauma experiences throughout their lifetime and psychological conditions. A total of 60 participants without any history of neurological problems participated in the fNIRS test, stratified by suicidality. This study was approved by the IRB of Korea University Ansan Hospital (2022AS0129).
To compare hemodynamic signal differences over the FPC before and after the various emotional face recognition task, we designed five repeated fNIRS experiment sessions using Yonsei Face Database (YFaceDB). The fNIRS device utilized in this study was NIRSIT (OBELAB, www.obelab.com), and the acquired fNIRS data underwent meticulous preprocessing to enhance its quality and reliability. This involved filtering techniques to mitigate high-frequency noise, baseline correction to address signal drift, systematic removal of motion artifacts, and precise spatial registration to align channels across participants. The feature extraction process aimed to unveil meaningful patterns in prefrontal neural activity during emotional processing. Hemodynamic response modeling captured changes in oxygenated and deoxygenated hemoglobin concentrations, providing dynamic insights. All processing steps were performed using the Homer2 Toolbox within the MATLAB environment.
Additional analyses were also conducted to explore potential relationships between prefrontal activity patterns, depression, and cognition scores.
Results:
Among 359 participants who completed the comprehensive trauma history questionnaire, 175 (48.75%) participants were found to have experienced suicide ideation (n = 92, 25.56%), planning (n = 96, 26.74%), or attempts (n = 53, 14.85%) at least once throughout their lives. Significant differences in traumatic experiences, such as partner abuse and depression scores, were identified (p < 0.001), while no differences were found in sex or educational level.
Compared to the control group, participants with suicidality history exhibited significantly decreased average signal value difference measured before and after the emotional face recognition task over the right and left dorsolateral PFC area channels by the fNIRS measurement. (p < 0.001).
Conclusions:
In this study, we focus on functional alterations over the PFC in Korean Baby Boomers with suicidal ideation history, specifically linked to past traumatic experiences. Utilizing fNIRS, we examined cortical dynamics to identify the intricate interplay between prefrontal brain activity, suicidality, and trauma to understand underlying neural mechanisms contributing to psychological distress. This research significantly contributes to understanding prefrontal function in the context of suicide risk among Korean Baby Boomers, with implications for targeted therapeutic interventions and improved mental health support.
ACKNOWLEDGEMENT: This study was supported by grants from the Korea University Ansan Hospital [No. K2316061 to H.J.Kim], Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by Ministry of Education [NRF-RS-NRF- 2021R1I1A1A01056054 to H. Cho and R2114233 to S. Son].
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 2
Emotion, Motivation and Social Neuroscience:
Emotional Perception
Lifespan Development:
Lifespan Development Other
Novel Imaging Acquisition Methods:
NIRS 1
Keywords:
Emotions
Near Infra-Red Spectroscopy (NIRS)
Psychiatric
1|2Indicates the priority used for review
Provide references using author date format
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