Poster No:
85
Submission Type:
Abstract Submission
Authors:
Chunlei Guo1, Jifei Sun2, Yue Ma3, Shanshan Gao4, Yi Luo5, Qingyan Chen6, Jiliang Fang6
Institutions:
1Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing, BeiJing, 2BeiJing Hospital Traditional Chinese Medicine, BeiJing, BeiJing, 3Guanganmen Hospital, China Academy of Chinese Medi, Beijing, China, 4Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Beijing, 5Guang’anmen Hospital of Chinese Academy of Traditional Chinese Medicine, Beijing, Beijing, 6Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China
First Author:
Chunlei Guo
Guanganmen Hospital, China Academy of Chinese Medical Sciences
Beijing, BeiJing
Co-Author(s):
Jifei Sun
BeiJing Hospital Traditional Chinese Medicine
BeiJing, BeiJing
Yue Ma
Guanganmen Hospital, China Academy of Chinese Medi
Beijing, China
Shanshan Gao
Guanganmen Hospital, China Academy of Chinese Medical Sciences
Beijing, Beijing
Yi Luo
Guang’anmen Hospital of Chinese Academy of Traditional Chinese Medicine
Beijing, Beijing
Qingyan Chen
Guanganmen Hospital, China Academy of Chinese Medical Sciences
Beijing, China
Jiliang Fang
Guanganmen Hospital, China Academy of Chinese Medical Sciences
Beijing, China
Introduction:
Major depressive disorder(MDD) is a condition with high recurrence rate and high disability rate[1]. Unfortunately, the effect of antidepressants are poor currently[2]. It is necessary to find a new treatment for MDD. Transcutaneous aurucular vagus nerve stimulation(taVNS) is confirmed to be effective for MDD[3], but it's mechanism is unclear. Therefore, this study employed resting-state BLOD-fMRI to explore the brain mechanism of taVNS in the treatment of MDD.
Methods:
Including 63 MDD patients and 68 healthy controls (HCs) matching sex, age and education, MDD patients were treated with taVNS for 8 weeks, and 17 items of Hamilton Depression Scale (17-HAMD) and Hamilton Anxiety Scale (HAMA) were evaluated before and after treatment, and resting-state BOLD-fMRI data were collected at the same time. HCs were not treated, only evaluate 17-HAMD and HAMA and scan resting-state BOLD-fMRI once when entering the group. DPABI was used to preprocess the resting-state BOLD-fMRI data, calculating the low frequency amplitude (ALFF), and then use the ALFF result of the baseline as the seed point to calculate function connectivity (FC). The results before and after treatment of taVNS were analyzed in a partial correlation with the clinical scale.
Results:
After 8 weeks of taVNS treatment, the depression and anxiety symptoms of MDD patients improved. Compared with HCs, the ALFF values of the right Frontal_Med_Orb (MOFC) of MDD patients were increased, and the FC values of right MOFC and left MOFC were increased. Compared with before treatment, the ALFF value of the right putamen was reduced, and the FC value of the right MOFC and the right Frontal_Inf_Oper, the right superior temporal gyrus, the left middle temporal gyrus and the right supp;ementary motor area (SMA) were reduced. Among them, the FC difference between the right MOFC and the right SMA before and after treatment is significantly negatively correlated with the 17-HAMD score difference before and after treatment.
Conclusions:
taVNS may play an antidepressant role by reducing the FC values of right MOFC and right SMA in MDD patients.
Brain Stimulation:
Non-Invasive Stimulation Methods Other 1
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 2
Keywords:
Affective Disorders
fMRI CONTRAST MECHANISMS
Therapy
Other - transcutaneous auricual vagus nerve stimulation(taVNS)
1|2Indicates the priority used for review
Provide references using author date format
[1]Schechter LE. Major depressive disorder. Curr Pharm Des. 2005;11(2):143-4.
Vöhringer PA, Ghaemi SN. Solving the antidepressant efficacy question: effect sizes in major depressive disorder. Clin Ther. 2011 Dec;33(12):B49-61.
Wang L, Wang Y, Wang Y, Wang F, Zhang J, Li S, Wu M, Li L, Rong P. Transcutaneous auricular vagus nerve stimulators: a review of past, present, and future devices. Expert Rev Med Devices. 2022 Jan;19(1):43-61.