Poster No:
416
Submission Type:
Abstract Submission
Authors:
Wei-ting Ko1, Chih-Min Liu1, Susan Shur-Fen Gau1
Institutions:
1Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan
First Author:
Wei-ting Ko
Department of Psychiatry, National Taiwan University Hospital
Taipei, Taiwan
Co-Author(s):
Chih-Min Liu
Department of Psychiatry, National Taiwan University Hospital
Taipei, Taiwan
Susan Shur-Fen Gau
Department of Psychiatry, National Taiwan University Hospital
Taipei, Taiwan
Introduction:
Autism spectrum disorder (ASD) and schizophrenia spectrum disorder (SCZ) were heritable and polygenetic neuropsychiatric disorders. Shared genetic factors between ASD and SCZ modulated grey matter volume. Previous studies reported that adults with ASD have greater regional gray matter volume (rGMV) in the middle and superior temporal gyrus, postcentral gyrus, and parahippocampal gyrus and reduced rGMV in the anterior cingulate cortex and cerebellum oppositely. In SCZ, rGMV loss in left insula, amygdala, and parahippocampus happened at the beginning oThe aim of our study was to compare rGMV between SCZ, ASD, and HC in a single MRI and analyzed the correlation between rGMV and symptomatology.
Methods:
SCZ, ASD, and HC were aged 18-28. SCZ group included schizophrenia, schizophreniform disorder, and first-episode psychosis according Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). The inclusive criteria of ASD based on the DSM-IV and DSM-5 diagnostic criteria for ASD. We used the Positive and Negative Syndrome Scale to measure the symptoms of SCZ and the Social Responsiveness Scale to assess the social deficit and autistic traits of ASD. We applied a three-dimensional magnetization-prepared rapid gradient-echo sequence in a 3T MRI system (Trio, Siemens, Erlangen, Germany) to acquire high-resolution T1-weighted image. Cat12 toolbox (http://dbm.neuro.uni-jena.de/cat/) implemented in SPM12 (http://www.fil.ion.ucl.ac.uk/spm/software/spm12/) were used to extract individual's regional rGMV according to neuromorphometrics atlas (https://www.neuromorphometrics.com/). One-way analysis of covariance (covariate variables were age, sex, and total intracranial volume) performed on the SAS 9.4 software (SAS Institute Inc., Cary, NC). We also applied post-hoc pairwise comparison and multiple-comparison correction. We calculated the Pearson's correlation coefficient between rGMVs and symptomology.
Results:
We finally included 64 SCZ (57 males), 75 ASD (64 males), and 107 HC (92 males). The mean age (SD) of SCZ was 22.85 (2.57), ASD was 21.22 (2.33) and HC was 22.31 (2.86). SCZ has extensive rGMV loss apart from bilateral pallidum, which was larger than ASD and HC. The direction of post-hoc analyses were (1) ASD> SCZ: right (R) precuneus gyrus, R parahippocampal gyrus (PHG), and left (L) parahippocampal gyrus. (2) HC, ASD >SSD: R Amygdala, bilateral hippocampus, R ventral diencephalon, bilateral anterior cingulate gyrus (ACG), bilateral anterior insula (AIN), R angular gyrus, L central operculum (CO), bilateral frontal operculum (FO), bilateral fusiform gyrus (FG), R inferior occipital gyrus, L inferior temporal gyrus, R lingual gyrus, bilateral middle cingulate gyrus, R superior frontal gyrus (SFG) medial segment, bilateral middle temporal gyrus, bilateral occipital fusiform gyrus, R posterior cingulate gyrus, bilateral posterior insula, L parietal operculum, R superior frontal gyrus, R supplementary motor cortex, bilateral supramarginal gyrus (SPMG), and bilateral superior temporal gyrus (STG). (3) HC>SSD: L amygdala, L middle frontal gyrus, and R temporal pole. SCZ's rGMVs were statistically significant low to moderate negative correlations with psychiatric symptoms (disorganization symptoms: bilateral AIN and FO; positive symptoms: bilateral FG, R SFG, L SPMG, R STG, and R PHG; excitement symptoms: bilateral pallidum; emotional distress: L posterior insula). ASD's rGMV were statistically significant low negative correlations with autistic symptoms (social emotions: R STG, R amygdala, R precuneus; social awareness: R ACG and L CO; social communication deficits: R SPMG).
Conclusions:
First, we found that SCZ has diffuse grey matter reduction in multiple brain regions comparing with healthy controls and ASD. Second, the rGMVs between ASD and HC were not significantly different. Third, the rGMVs in ASD and SSD have associations with their symptomology, respectively.
Disorders of the Nervous System:
Neurodevelopmental/ Early Life (eg. ADHD, autism) 1
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 2
Neuroanatomy, Physiology, Metabolism and Neurotransmission:
Cortical Anatomy and Brain Mapping
Keywords:
ADULTS
Autism
Cortex
Morphometrics
MRI
Psychiatric Disorders
Schizophrenia
STRUCTURAL MRI
Structures
Other - grey matter
1|2Indicates the priority used for review
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