Distinctive Accumulation Patterns of Amyloid β in clinical progression of MCI pattern
Poster No:
262
Submission Type:
Abstract Submission
Authors:
SeonKyeong Kim1, Yunjin Lee1, Wonjae Sung2, Yong Sung Kim2, Sujin Lee2, June Sic Kim3, HeeJin Kim2
Institutions:
1Hanyang University, Seoul, Korea, Republic of, 2Hanyang University Medical Center, Seoul, Korea, Republic of, 3Konkuk University Medical Center, Seoul, Korea, Republic of
First Author:
Co-Author(s):
Introduction:
Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and dementia. Understanding underlying pathological background is critical to predict clinical progression and disease management. Amyloid Positron Emission Tomography (PET) imaging uses a class of radiopharmaceuticals that detect levels of amyloid in the human brain to visualize amyloid beta deposits, It has revealed brain pathology and faster clinical progression of Alzheimer's disease (AD). Previous studies primarily focused on the total amount of amyloid without conducting longitudinal studies. This study aims to explore distinct amyloid beta accumulation patterns in individuals with stable MCI compared to those progressing to dementia in definite prodromal AD patients.
Methods:
Forty-five MCI patients participated. 23 of these patients were converted into AD. Amyloid β deposition was quantified using the Standardized Uptake Value Ratio(SUVR) and the Centiloid, a standardized metric for PET data. Subsequently, an one sample t-test was employed to assess the statistical significance between the two groups, which analyzes differences in amyloid deposition patterns and their respective SUVR and Centiloid values.
Results:
The analysis revealed a statistically significant elevation in both SUVR and Centiloid values in the right Lateral orbital gyrus (OFClat) region for the MCI to AD group compared to the MCI to MCI group. The increase in SUVR and Centiloid scores in this specific region was consistent with the hypothesis of heightened amyloid beta accumulation in individuals progressing from MCI to AD.
Conclusions:
Our findings suggest that early amyloid beta deposition in the right Lateral orbital gyrus region may serve as a biomarker for the early detection of AD progression risk.
Disorders of the Nervous System:
Neurodegenerative/ Late Life (eg. Parkinson’s, Alzheimer’s) 1
Modeling and Analysis Methods:
PET Modeling and Analysis 2
Keywords:
Aging
Data analysis
Memory
Nerves
Neurological
Positron Emission Tomography (PET)
1|2Indicates the priority used for review
Provide references using author date format
- ‘Laboratory of Neuro Imaging Resource Innovative solutions for the investigation of imaging, genetics, behavioral, and clinical data’, Keck, School of Medicine of USC, University of Southern California
- Gary W. Van Hoesen (2000), ‘Orbitofrontal Cortex Pathology in Alzheimer's Disease’, Cerebral Cortex, Vol. 10, Issue 3, Pages 243–251.