Common and unique alterations of functional connectivity and topology in affective disorder
Poster No:
621
Submission Type:
Abstract Submission
Authors:
Hao Sun1, Rui Yan2, Xiaoqin Wang3, Lingling Hua4, Zhilu Chen5, Yinghong Huang6, YISHAN DU4, Yingying Huang4, Moxuan Song6, Na Shen7, Qing Lu8, Zhijian Yao1
Institutions:
1Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, 2Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 3Nanjing medical university, Nanjing, Jiangsu, 4Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 5the Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 6The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 7Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing, Jiangsu, 8Southeast University, Nanjing, Jiangsu
First Author:
Hao Sun
Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University
Nanjing, Jiangsu
Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University
Nanjing, Jiangsu
Co-Author(s):
Rui Yan
Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Lingling Hua
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
YISHAN DU
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Yingying Huang
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Zhijian Yao
Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University
Nanjing, Jiangsu
Nanjing Brain Hospital, Clinical Teaching Hospital of Medical School, Nanjing University
Nanjing, Jiangsu
Introduction:
Unipolar disorder (UD) and bipolar disorder (BD) are supposed to be whole-brain diseases with some shared clinical and neuropathology characteristics. It is important to study the neural mechanisms that distinguish between the two diseases. This study aims to explore the different neural mechanisms of functional connectivity and topology properties between BD and UD.
Methods:
In this study, 265 patients with UD, 181 patients with BD, and 204 healthy controls completed Hamilton Depression Scale (HAMD) assessment and resting-state functional magnetic resonance imaging (rfMRI) scans. Functional connectivity of BD, UD and HC were compared. On the basis of the network alterations shared by BD and UD, the topological pattern of the two groups were analysed.
Results:
Both BD and UD showed decreased FC in the whole-brain, mainly involving VN, SMN and DMN. Topological attribute analyses are carried out on nodes of SMN, DMN and VN. Results suggesting that both BD (t=-2.093, p=0.037) and UD (t=-2.406, p=0.017) showed a decrease in Cp. While only the BD group showed a decrease in Lp (t = -2.888, p = 0.004) and an increase in Eglob (t = 3.402, p < 0.001).
Conclusions:
Our findings suggest that both BD and UD are disease with a wide range abnormal brain networks, mainly associated with VN, SMN and DMN. Unique topological characteristics alterations were only found in BD, which may provide possible characteristic markers to distinguish the two disorders.
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Modeling and Analysis Methods:
fMRI Connectivity and Network Modeling 2
Keywords:
FUNCTIONAL MRI
1|2Indicates the priority used for review
