Is the neural oscillation in the pars opercularis of the rIFG related to antidepressant efficacy?
Poster No:
612
Submission Type:
Abstract Submission
Authors:
Tingting Xiong1, Lingling Hua1, Moxuan Song2, Yingying Huang1, Zhijian Yao2, Qing Lu3
Institutions:
1Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 2The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 3Southeast University, Nanjing, Jiangsu
First Author:
Tingting Xiong
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Co-Author(s):
Lingling Hua
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Yingying Huang
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Department of Psychiatry, the Affiliated Brain Hospital of Nanjing Medical University
Nanjing, Jiangsu
Introduction:
In this study, we intend to explore the neuropathological mechanism of response inhibition deficit in depression by studying the local activity and whole-brain functional connectivity of beta frequency band in the pars opercularis of the right inferior frontal gyrus(rIFG) at the baseline period, to further investigate its association with the early efficacy of antidepressant drugs.
Methods:
A total of 52 depressed patients and 26 healthy controls were included, All subjects completed a cranial magnetic resonance scan and magnetoencephalographic data acquisition under the Go/No-Go experimental paradigm at baseline. Meanwhile, a weekly assessment of the HAMD scale was performed to assess the efficacy without interfering with the patient's actual clinical treatment. The group of MDD patients was divided into Early responders and Early Nonresponders based on whether the reduction in total HAMD score at the end of 2-week treatment was ≥50%. Based on the AAL90 template, the pars opercularis of the rIFG was used as a seed point to establish functional connectivity with other brain regions in the whole brain. Also, Event-Related Desynchronization (ERD) in the beta frequency band of the pars opercularis of the rIFG of all subjects at baseline was compared between the three groups, In order to identify the differences and to analyze its correlation with the 2-week rate of reduction in the total HAMD score and each factor score, which was used to explore the best markers for differentiating the early efficacy of antidepressants.
Results:
Functional connectivity in the beta band of the pars opercularis of the rIFG to other brain regions in the whole brain was reduced in the depressed group when compared to the healthy control group at baseline (F = 5.093, P = 0.008). whereas there was no significant difference in functional connectivity between Early responders and Early Nonresponders (P > 0.05); Compared with the healthy control group, Early responders and Nonresponders both showed a decrease in ERD of the beta frequency band in the pars opercularis of the rIFG during the baseline period (P < 0.05); Compared with Early responders, Early Nonresponders had a worse degree of desynchronization related to the pars opercularis of the rIFG (P < 0.05); The ERD in the beta frequency band during the baseline period was negatively correlated with the 2-week rate of reduction in the total HAMD score (r = -0.364, P = 0.008)、Cognitive impairment factor(r =-0.365, P =0.008) and Block factor (r =-0.441, P =0.001).
Conclusions:
The pars opercularis of the rIFG in depressed patients suffers from both impaired function of its own and decreased synergism with other brain regions, which may be a pathophysiological mechanism for the response inhibition deficit in depression; the predictive value of functional connectivity between the pars opercularis of the rIFG and other brain regions for the Early efficacy evaluation still needs to be further explored; ERDs in the beta band of this region can be used as a biomarker related to the early efficacy of antidepressant drugs, which can provide a certain objective basis for whether cognitive deficits and psychomotor block symptoms can be effectively improved in patients with depression after 2 weeks.
Brain Stimulation:
Non-invasive Magnetic/TMS 2
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Keywords:
MEG
Neuron
1|2Indicates the priority used for review
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2. Hack, L. M., Tozzi, L., Zenteno, S., Olmsted, A. M., Hilton, R., Jubeir, J., Korgaonkar, M. S., Schatzberg, A. F., Yesavage, J. A., O'Hara, R., & Williams, L. M. (2023). A Cognitive Biotype of Depression and Symptoms, Behavior Measures, Neural Circuits, and Differential Treatment Outcomes: A Prespecified Secondary Analysis of a Randomized Clinical Trial. JAMA network open, 6(6), e2318411
3. Schaum, M., Pinzuti, E., Sebastian, A., Lieb, K., Fries, P., Mobascher, A., Jung, P., Wibral, M., & Tüscher, O. (2021). Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans. eLife, 10, e61679
4. Tozzi, L., Goldstein-Piekarski, A. N., Korgaonkar, M. S., & Williams, L. M. (2020). Connectivity of the Cognitive Control Network During Response Inhibition as a Predictive and Response Biomarker in Major Depression: Evidence From a Randomized Clinical Trial. Biological psychiatry, 87(5), 462–472
5. Vermeiden, M., Kamperman, A. M., Vulink, M. E., van den Broek, W. W., & Birkenhäger, T. K. (2015). Early improvement as a predictor of eventual antidepressant treatment response in severely depressed inpatients. Psychopharmacology, 232(8), 1347–1356
6. Li, F. F., Chen, X. L., Zhang, Y. T., Li, R. T., & Li, X. (2021). The role of prepotent response inhibition and interference control in depression. Cognitive neuropsychiatry, 26(6), 441–454