Tourette and Chronic Tic disorders: Results from multimodal Brain Imaging Studies in Korea
Poster No:
410
Submission Type:
Abstract Submission
Authors:
Jae Hyun Yoo1, In-Hyang Kim2, Soo-Min Jang3, Woo-Seok Choi4, Yu-Bin Lim4, Bung-Nyun Kim4
Institutions:
1The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea, Republic of, 2Hanyang University Medical Center, Seoul, Not required for this country, 3SMG-SNU Boramae Medical Center, Seoul, Not required for this country, 4Seoul National University Hospital, Seoul, Not required for this country
First Author:
Co-Author(s):
Introduction:
Tic and tourette disorders are neurodevelopmental disorders that develop in early childhood. Literature suggested tic symptoms are associated with widespread structural changes including cortico–striatal–thalamocortical pathway and ascending cortical inputs. Still, methods and sample size have varied widely across imaging studies, findings from stuructural imaging have not been converged yet in tic disorder.
In the current study, we aimed to find neural correlates of tic disorder by exploring subcortical morphologic changes and associated anatomical connectivity findings.
In the current study, we aimed to find neural correlates of tic disorder by exploring subcortical morphologic changes and associated anatomical connectivity findings.
Methods:
Current study recruited 62 subjects with chronic tic disorder and 62 age-matched controls. To reveal collective alterations alongside subcortical structures and white matter, we sequentially analyzed multimodal imaging data. Using FIRST of FSL, comparison of morphologic alteration has been conducted using high-resolution T1-weighted images. Hence, regions with significant change inputted as seed mask for diffusion tractography by mrtrix3.
Results:
The shape ofsubcortical structure among participant with tic disorder showed significant shrinkage in posterodorsal facet of right amygdala (p=0.017), ventromedial facet of right putamen (corrected p=0.029), posterior and lateral facet right pallidum (corrected p=0.041), inferior and lateral facet of right thalamus (corrected p=0.030) and posterodorsal facet of left thalamus (corrected p =0.029). Seed based tractography revealed that
tic group showed reduced connectivity between right thalamus-right inferior insula (p=0.001), right thalamus-right posterior lateral fissure (p=0.043), and right putamen-right inferior insula (p=0.037). In contrast, connectivity between right putamen-right orbital area (p=0.028), and right pallidum-right caudate (p=0.013) was stronger in tic group than that of control group.
tic group showed reduced connectivity between right thalamus-right inferior insula (p=0.001), right thalamus-right posterior lateral fissure (p=0.043), and right putamen-right inferior insula (p=0.037). In contrast, connectivity between right putamen-right orbital area (p=0.028), and right pallidum-right caudate (p=0.013) was stronger in tic group than that of control group.
·Comparison of the subcortical shape differences between patients with Tourette's and chronic tic disorders and typically developing children
Conclusions:
Current study highlighted that children with chronic tic disorder had morphological changes across several subcortical regions including thalamus, putamen, pallidum and amygdala. In addition, cortical connectivity network from such regions are also well corresponded to neural correlates of genesis, premonitory urge, and suppression of tic.
·Subcortical-to-cortical network connectivity alterations in patients with Tourette's and chronic tic disorders estimated from current fiber tractography findings
Disorders of the Nervous System:
Neurodevelopmental/ Early Life (eg. ADHD, autism) 1
Modeling and Analysis Methods:
Connectivity (eg. functional, effective, structural) 2
Keywords:
Basal Ganglia
STRUCTURAL MRI
Sub-Cortical
Tourette's Syndrome
Tractography
WHITE MATTER IMAGING - DTI, HARDI, DSI, ETC
1|2Indicates the priority used for review
Provide references using author date format
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