Disrupted development of cortical-amygdala functional connectivity following childhood maltreatment,
Poster No:
1550
Submission Type:
Abstract Submission
Authors:
Yu Mao1
Institutions:
1Yu Mao, Postdoctor, Southwest University, Chongqing, GA
First Author:
Introduction:
Childhood maltreatment (CM) is characterized by significant impairment in emotion processing and regulation, through the dysregulation of the cortical-limbic pathway, however, there is little longitudinal evidence on the neurobiological influence of CM. This study is designed to explore the influence of CM on cortical-amygdala functional connectivity (FC) and further reveal the longitudinal changes cortical-amygdala FC following CM.
Methods:
First, the relationship between CM and cortical-amygdala FC was tested in two independent datasets of healthy young adults, controlling for the current life stress. Then, a linear mixed effects model was used test the interaction of time and CM score on the longitudinal changes in cortical-amygdala FC, using a dataset with resting-state fMRI data acquired at two different time points (mean time interval = 725 days). Finally, we explored the associations between disrupted developed pattern following CM experience and the latent vulnerability of emotional problem, using a moderated mediation analysis.
Results:
We herein report three main findings. First, our results support the hypothesis that CM is characterized by reduced cortical-amygdala FC, in a reliable and reproducible manner. Second, the longitudinal results revealed individuals with higher level of CM demonstrated higher level of increase in cortical-amygdala connectivity, compared with individuals with lower level of CM. Third, among individuals with higher level of CM, higher level of increase of cortical-amygdala connectivity was associated with higher risk of emotional problem risk under stressful life events.
·Figure 1. The relationship between CM and amygdala related functional connectivity.
·Figure 2. Longitudinal changes of DLPFC-amygdala FC various across different CM groups. Panel A shows the age distribution of the longitudinal dataset. Panel B shows the developmental trajectory of DL
Conclusions:
These results suggested that CM was associated with reduced amygdala connectivity with brain regions involving cognitive control and emotion regulation. Furthermore, these atypical development of cortical-amygdala FC in individuals with higher level of CM might symbolize the latent vulnerability for future risk of emotional problems.
Emotion, Motivation and Social Neuroscience:
Emotion and Motivation Other 2
Modeling and Analysis Methods:
Connectivity (eg. functional, effective, structural) 1
Keywords:
FUNCTIONAL MRI
Limbic Systems
Trauma
1|2Indicates the priority used for review
Provide references using author date format
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