DCE-MRI shows higher Blood–Brain Barrier leakage in first-episode Schizophrenia Spectrum Disorders
Poster No:
594
Submission Type:
Abstract Submission
Authors:
Joanna Moussiopoulou1, Vladislav Yakimov1, Boris Rauchmann1, Hannah Toth1, Julian Melcher1, Iris Jäger1, Isabel Lutz1, Marcel Kallweit1, Boris Papazov2, Klaus Seelos3, Amir Dehsarvi4, Lukas Röll1, Elias Wagner1, Nicolai Franzmeier4, Daniel Keeser1,5
Institutions:
1Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany, 2Department of Radiology, LMU University Hospital, Munich, Germany, 3Institute of Neuroradiology, LMU University Hospital, Munich, Germany, 4Institute for Stroke and Dementia Research (ISD), LMU University Hospital, Munich, Germany, 5NeuroImaging Core Unit Munich (NICUM), Munich, Germany
First Author:
Joanna Moussiopoulou
Department of Psychiatry and Psychotherapy, LMU University Hospital
Munich, Germany
Department of Psychiatry and Psychotherapy, LMU University Hospital
Munich, Germany
Co-Author(s):
Vladislav Yakimov
Department of Psychiatry and Psychotherapy, LMU University Hospital
Munich, Germany
Department of Psychiatry and Psychotherapy, LMU University Hospital
Munich, Germany
Amir Dehsarvi
Institute for Stroke and Dementia Research (ISD), LMU University Hospital
Munich, Germany
Institute for Stroke and Dementia Research (ISD), LMU University Hospital
Munich, Germany
Nicolai Franzmeier
Institute for Stroke and Dementia Research (ISD), LMU University Hospital
Munich, Germany
Institute for Stroke and Dementia Research (ISD), LMU University Hospital
Munich, Germany
Daniel Keeser
Department of Psychiatry and Psychotherapy, LMU University Hospital|NeuroImaging Core Unit Munich (NICUM)
Munich, Germany|Munich, Germany
Department of Psychiatry and Psychotherapy, LMU University Hospital|NeuroImaging Core Unit Munich (NICUM)
Munich, Germany|Munich, Germany
Introduction:
Previous studies that investigated disruptions in CNS barriers in schizophrenia spectrum disorders (SSD) mainly focused on changes in the cerebrospinal fluid (CSF), that only indirectly and inadequately allows conclusions about the blood-brain barrier (BBB). Dynamic contrast-enhanced MRI represents a sensitive method for investigating subtle barrier breakdown. Only one study so far investigated BBB breakdown in SSD with DCE-MRI, in a relatively small cohort. We hypothesized higher leakage in SSD compared to HC, that is indicative for a clinical sub-phenotype of SSD.
Methods:
45 people with SSD and 42 age- and sex-matched healthy controls (HC) were included in the study and 41 SSD and 40 HC were included in the final analyses. Structural and DCE-MRI were performed cross-sectionally. Clinical characterization, cognitive assessments, blood and CSF analysis were conducted. The analysis software ROCKETSHIP was used for DCE-MRI quantification and pharmacokinetic modelling (Patlak method) was implemented. The volume transfer constant Ktrans was calculated and Ktrans maps were compared between the groups to detect group differences in BBB leakage. Within the SSD cohort, the association of leakage with clinical characteristics was investigated.
Results:
Group comparisons of Ktrans maps showed higher leakage in the SSD cohort compared to HC on a whole brain level in multiple widely distributed brain regions. The effect was stronger in first episode compared to multiple episode SSD patients. No association was detected between leakage and cognition, psychopathology, peripheral inflammation and Albumin serum/CSF ratio.
Conclusions:
This is the study with the largest cohort to investigate the blood-brain barrier (BBB) in SSD with DCE-MRI, allowing direct exploration of the BBB, compared to a healthy control group and the first study to implement this modality in a multimodal approach, with CSF, blood, clinical and cognitive assessments. The results provide the first in vivo evidence of higher BBB leakage on a whole brain level compared to HC.
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Modeling and Analysis Methods:
Other Methods 2
Physiology, Metabolism and Neurotransmission :
Physiology, Metabolism and Neurotransmission Other
Keywords:
Other - Blood-brain barrier, DCE-MRI, leakage, Schizophrenia
1|2Indicates the priority used for review
·SSD vs. HC Ktrans map comparison (SPM12)
·FEP vs. nFEP SSD vs. HC Ktrans map comparison (SPM12)
Provide references using author date format
Patlak, C.S., R.G. Blasberg, and J.D. Fenstermacher, Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab, 1983. 3(1): p. 1-7.