Poster No:
714
Submission Type:
Abstract Submission
Authors:
Vesa Putkinen1
Institutions:
1University of Turku, Turku, US and Canada only
First Author:
Introduction:
Music is as a common source of pleasure for most people, and activates the same hedonic brain circuitry supporting pleasure derived from other rewarding experiences. Yet, little is known about the brain metabolic demands induced by pleasurable music-listening. Here, we utilize simultaneous functional [18F]FDG-PET and functional magnetic resonance imaging (fMRI) to measure concurrent changes in brain glucose metabolism and hemodynamic activity during music-induced pleasure. Unlike PET imaging with the traditional bolus administration of the tracer, fPET employs constant FDG infusion and allows the quantification of task-specific changes in glucose metabolism in a single scan.
Methods:
Twenty-seven subjects underwent a 90-min simultaneous PET-MRI recording. Twenty percent of the tracer was administered in a bolus followed by a constant infusion across the entire scan. The experiment included two 10-min blocks of self-selected pleasurable music and two 10-min blocks neutral auditory stimulation. During the blocks, 45-sec sound stimulation (music or control stimuli) altered with 15-sec silent periods.
For the PET data, voxel-vise time activity curves were modeled with a general linear model (GLM) with task-specific regressors for the Music and Control conditions and a regressor for baseline metabolism. The fMRI data were modelled with a GLM with boxcar regressors (silence vs. sound stimulation) for the music and control blocks.
Results:
Pleasurable music listening increased FDG uptake in the auditory cortex, right inferior frontal gyrus, the pre- and post-central gyri, and in limbic regions such as the nucleus accumbens. The fMRI results replicated these findings showing increased in haemodynamic activity in the auditory, motor and limbic regions during pleasurable music.
Conclusions:
Our results indicate that pleasurable music induces heightened energy consumption in the sensory, motor and emotion circuits of the brain. The results confirm the feasibility of simultaneous fPET-fMRI in studying the metabolic and haemodynamic changes associated with music-induced pleasure. The imaging modalities provided both converging and unique information about the neural underpinning of music-induced pleasure. Simultaneous fPET-fMRI presents novel possibilities for functional brain imaging of human emotions.
Emotion, Motivation and Social Neuroscience:
Emotional Perception
Emotion and Motivation Other 1
Higher Cognitive Functions:
Music 2
Modeling and Analysis Methods:
PET Modeling and Analysis
Physiology, Metabolism and Neurotransmission :
Cerebral Metabolism and Hemodynamics
Keywords:
Emotions
FUNCTIONAL MRI
Positron Emission Tomography (PET)
1|2Indicates the priority used for review
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Hahn, A., Gryglewski, G., Nics, L., Hienert, M., Rischka, L., Vraka, C., Sigurdardottir, H., Vanicek, T., James, G. M., Seiger, R., Kautzky, A., Silberbauer, L., Wadsak, W., Mitterhauser, M., Hacker, M., Kasper, S., & Lanzenberger, R. (2016). Quantification of Task-Specific Glucose Metabolism with Constant Infusion of 18F-FDG. Journal of Nuclear Medicine, 57(12), 1933–1940. https://doi.org/10.2967/jnumed.116.176156
Koelsch, S. (2014). Brain correlates of music-evoked emotions. Nature Reviews. Neuroscience, 15(3), 170–180. https://doi.org/10.1038/nrn3666