Filler word-related cortical high-gamma modulations in the visual and auditory cortex
Poster No:
2619
Submission Type:
Abstract Submission
Authors:
Riri Kimura1, Yu Kitazawa2, Ayame Yamagishi3, Risa Hikino2, Hiroshi Uda4, Naoto Kuroda5, Shin-ichiro Osawa6, keiya Iijima7, Kyoko Suzuki8, Nobukazu Nakasato6, Masaki Iwasaki9, Eishi Asano4
Institutions:
1Yokohama City University, Saitama, Urawa, 2Yokohama City University, Yokohama, Kanagawa, 3Yokohama City University, Kawasaki, Kanagawa, 4Wayne State University, Detroit, MI, 5Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State Unive, Detroit, MI, 6Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 7Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Tokyo, 8Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of, Sendai, Miyagi, 9National Center Hospital, Tokyo, Tokyo
First Author:
Co-Author(s):
Naoto Kuroda
Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State Unive
Detroit, MI
Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State Unive
Detroit, MI
Shin-ichiro Osawa
Department of Epileptology, Tohoku University Graduate School of Medicine
Sendai, Miyagi
Department of Epileptology, Tohoku University Graduate School of Medicine
Sendai, Miyagi
keiya Iijima
Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry
Tokyo, Tokyo
Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry
Tokyo, Tokyo
Kyoko Suzuki
Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of
Sendai, Miyagi
Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of
Sendai, Miyagi
Nobukazu Nakasato
Department of Epileptology, Tohoku University Graduate School of Medicine
Sendai, Miyagi
Department of Epileptology, Tohoku University Graduate School of Medicine
Sendai, Miyagi
Introduction:
A previous study of three participants reported high-gamma band EEG activation, an intracranial measure of neural excitation, in the visual association cortex when patients uttered filler words such as "um" or "like" during an visual task.1The present study of a large cohort of patients determined whether and when visual and auditory cortices are involved in uttering filler words.
Methods:
We investigated 40 patients with drug-resistant focal epilepsy who underwent epilepsy surgery. During intracranial EEG (iEEG) recordings, patients engaged in an auditory descriptive naming task, which comprised 96 questions such as "When do you eat breakfast?" Using time-frequency iEEG analysis, we identified differential cortical high-gamma modulations between "filler words" and "ordinary word responses" in the superior temporal gyrus (STG) and lateral occipital gyrus (LOG). This analysis focused on patients who uttered ten or more filler words during the naming task.
Results:
Fifteen patients uttered filler words ten or more times. In the STG, significant high-gamma augmentation was observed immediately after the onset of ordinary and filler words. Notably, there was a greater high-gamma augmentation during ordinary word compared to filler word utterance (Fig. 1). Conversely, in the left LOG, significant high-gamma augmentation was observed around the filler word offset alone (Fig. 1 and 2).
Conclusions:
This study demonstrated differential activation in auditory and visual cortices associated with filler and ordinary word utterances. The less enhanced activation in the STG during filler word utterance, compared to ordinary word responses, may imply a reduced need of monitoring of own filler words. Conversely, the more enhanced activation in the left LOG during filler word utterance, compared to ordinary word responses, could suggest the involvement of the visual association cortex in a form of visual scene scanning to facilitate word retrieval.
Language:
Language Comprehension and Semantics
Speech Production 2
Neuroinformatics and Data Sharing:
Brain Atlases
Novel Imaging Acquisition Methods:
EEG
Physiology, Metabolism and Neurotransmission :
Neurophysiology of Imaging Signals 1
Keywords:
Atlasing
Electroencephaolography (EEG)
Epilepsy
Language
Other - filler words, auditory descriptive naming task, high-gamma, time-frequency analysis
1|2Indicates the priority used for review