Cortical Gyrification Abnormalities in Pediatric and Adult Obsessive-Compulsive Disorder
Poster No:
562
Submission Type:
Abstract Submission
Authors:
Inkyung Park1, Minah Kim2, Minji Ha1, Dan Stein3, Odile van den Heuvel4, Paul Thompson5, Jun Soo Kwon2
Institutions:
1Seoul National University, Seoul, South Korea, 2Seoul National University Hospital, Seoul, South Korea, 3University of Cape Town, Cape Town, South Africa, 4Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, and Department of Anatomy and, Amsterdam, Netherlands, 5USC, Marina Del Rey, CA
First Author:
Co-Author(s):
Odile van den Heuvel
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, and Department of Anatomy and
Amsterdam, Netherlands
Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, and Department of Anatomy and
Amsterdam, Netherlands
Introduction:
To better understand the complexities of obsessive-compulsive disorder (OCD), it is crucial to identify more homogeneous subtypes of patients with OCD based on biological evidence. The age of onset has been used as a criterion for subtyping, reliably distinguishing between early-onset and late-onset OCD subgroups in accordance with distinct neurodevelopmental perspectives. Cortical folding is primarily determined during the embryonic and early postnatal developmental period and maintains its pattern relatively stable over the lifespan, thus serving as a reliable neurobiological marker for early neurodevelopmental deficits in psychiatric illnesses. The presence of gyrification abnormalities in both adult early-onset OCD and pediatric OCD patients was investigated to categorize OCD into more biologically-based and homogeneous subtypes based on underlying neurodevelopmental origins.
Methods:
The local Gyrification Index (lGI) data from 2611 OCD patients and 2723 HCs, collected from 32 sites (52 datasets) worldwide as part of the ENIGMA OCD Working Group, were pooled for mega-analyses. Whole-brain lGI data were harmonized using ComBat to account for site and scanner effects within a mega-analysis framework. The vertex-wise lGI group comparisons were conducted between pediatric OCD patients and pediatric HCs, as well as among adult patients with early-onset OCD, late-onset OCD, and adult HCs using a general linear model implemented in Freesurfer while controlling for age and sex.
Results:
Adult patients with early-onset OCD displayed significantly greater gyrification in the bilateral fronto-parietal cortex. This included clusters with peak vertices in the left caudal middle frontal, postcentral, lateral orbitofrontal, and another caudal middle frontal gyri, as well as in the right precentral and inferior parietal gyri. Conversely, adult patients with late-onset OCD exhibited significantly reduced gyrification in corresponding regions, with peak vertices located in the left precentral and lingual gyri, as well as the right superior frontal and inferior temporal gyri. Adult patients with early-onset OCD showed significant hypergyrification compared to those with late-onset OCD in similar but more extensive regions of fronto-parietal, temporal, medial occipital, and cingulate regions. In pediatric OCD patients compared to pediatric HCs, significantly increased gyrification was also observed in bilateral fronto-parietal, temporal, and cingulate regions. Furthermore, hypergyrification in the left precentral, left posterior cingulate, right postcentral, and right superior frontal clusters was significantly correlated with an earlier age of onset, even after correction for multiple comparisons.
·Group differences in the whole-brain vertex-wise lGI between the adult OCD patients and adult HCs
·Group differences in the whole-brain vertex-wise lGI between the pediatric OCD patients and pediatric HCs
Conclusions:
Adult early-onset OCD patients consistently exhibited increased cortical gyrification, predominantly in fronto-parietal and cingulate regions. Additionally, more widespread hypergyrification deficits were consistently found in pediatric OCD patients, and the increased gyrification in the fronto-parietal and cingulate cortices was further correlated with the age of onset in pediatric OCD patients. Our findings, which consistently implicate abnormal hypergyrification in both adult early-onset OCD and pediatric OCD group, provide a potential neurobiological marker that can help categorize patients with OCD into more neurodevelopmentally homogeneous subtypes. This could enhance our understanding of the neurodevelopmental deficits contributing to the etiology of early-onset OCD, aligning with existing evidence suggesting that early-onset OCD has a greater neurodevelopmental loading than late-onset OCD.
Disorders of the Nervous System:
Neurodevelopmental/ Early Life (eg. ADHD, autism)
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Lifespan Development:
Lifespan Development Other
Novel Imaging Acquisition Methods:
Anatomical MRI 2
Keywords:
Cortex
MRI
Obessive Compulsive Disorder
Pediatric Disorders
STRUCTURAL MRI
Structures
Other - gyriciation
1|2Indicates the priority used for review
Provide references using author date format
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