Filler word-related high-gamma modulations in the sensorimotor cortex
Poster No:
2616
Submission Type:
Abstract Submission
Authors:
Risa Hikino1, Yu Kitazawa1, Riri Kimura2, Ayame Yamagishi3, Hiroshi Uda4, Naoto Kuroda5, Shin-ichiro Osawa6, keiya Iijima7, Kyoko Suzuki8, Nobukazu Nakasato6, Masaki Iwasaki7, Eishi Asano4
Institutions:
1Yokohama City University, Yokohama, Kanagawa, 2Yokohama City University, Saitama, Urawa, 3Yokohama City University, Kawasaki, Kanagawa, 4Wayne State University, Detroit, MI, 5Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State Unive, Detroit, MI, 6Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 7Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Tokyo, 8Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of, Sendai, Miyagi
First Author:
Co-Author(s):
Naoto Kuroda
Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State Unive
Detroit, MI
Department of Pediatrics, Children’s Hospital of Michigan, Detroit Medical Center, Wayne State Unive
Detroit, MI
Shin-ichiro Osawa
Department of Epileptology, Tohoku University Graduate School of Medicine
Sendai, Miyagi
Department of Epileptology, Tohoku University Graduate School of Medicine
Sendai, Miyagi
keiya Iijima
Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry
Tokyo, Tokyo
Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry
Tokyo, Tokyo
Kyoko Suzuki
Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of
Sendai, Miyagi
Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of
Sendai, Miyagi
Nobukazu Nakasato
Department of Epileptology, Tohoku University Graduate School of Medicine
Sendai, Miyagi
Department of Epileptology, Tohoku University Graduate School of Medicine
Sendai, Miyagi
Masaki Iwasaki
Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry
Tokyo, Tokyo
Department of Neurosurgery, National Center Hospital, National Center of Neurology and Psychiatry
Tokyo, Tokyo
Introduction:
The sensorimotor cortex plays a crucial role in speech production. Previous studies have reported excitation in the bilateral sensorimotor cortex around the onset of speech production∧1,2. However, the spatiotemporal dynamics of the sensorimotor cortex associated with filler word utterances, such as "um" and "well", commonly used to fill the silence during conversations, remains unclear. Therefore, we conducted intracranial EEG-based research to clarify when the sensorimotor cortex is activated.
Methods:
A total of 40 patients with drug-resistant focal epilepsy who underwent resective epilepsy surgery were studied. They participated in an auditory descriptive naming task, comprising 96 questions while intracranial EEG recordings were performed. Trials in which patients didn't respond to the question or stated "I have no idea" were excluded from the analysis. To characterize the dynamics of high-gamma modulations (70-110 Hz) in the sensorimotor cortex related to filler word and ordinary answer utterances, we performed a time-frequency analysis on 15 participants who uttered ten or more filler words during the task.
Results:
Both filler words and ordinary word answers induced a significant high-gamma augmentation in the bilateral sensorimotor cortices beginning just before the vocalization onset. After the offset of utterance, filler words induced more enhanced high-gamma augmentation in the bilateral sensorimotor cortices, compared to ordinary word answers.
Conclusions:
This study successfully identified the shared and differential neural dynamics associated with utterance of filler words and ordinary word answers in the sensorimotor cortex. Persistence of sensorimotor high-gamma augmentation following the offset of filler word utterances may indicate its involvement in response preparation after using filler words.
Language:
Language Comprehension and Semantics
Speech Production 2
Neuroinformatics and Data Sharing:
Brain Atlases
Novel Imaging Acquisition Methods:
EEG
Physiology, Metabolism and Neurotransmission :
Neurophysiology of Imaging Signals 1
Keywords:
Atlasing
Electroencephaolography (EEG)
Epilepsy
Language
Other - precentral gyrus; postcentral gyrus; functional mapping; filler words; intracranial EEG; high-gamma
1|2Indicates the priority used for review
Provide references using author date format
2. Kitazawa Y, et al. Intra– and inter–hemispheric network dynamics supporting object recognition and speech production. NeuroImage. 2023;270:119954.