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Reciprocal causation relationship between rumination and sleep quality: a resting-state fMRI study

Poster No:

2573

Submission Type:

Abstract Submission

Authors:

shiyan yang¹^,2, xu lei¹^,2

Institutions:

¹Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, chongqing, China, ²Key Laboratory of Cognition and Personality (Southwest University), Ministry of Education, chongqing, China

First Author:

shiyan yang
Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University|Key Laboratory of Cognition and Personality (Southwest University), Ministry of Education
chongqing, China|chongqing, China

Co-Author:

xu lei
Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University|Key Laboratory of Cognition and Personality (Southwest University), Ministry of Education
chongqing, China|chongqing, China

Introduction:

Rumination thinking is a type of negative repetitive thinking, a tendency to constantly focus on the causes, consequences and other aspects of negative events, which has implications for a variety of psychiatric disorders. Previous studies have confirmed a strong association between rumination thinking and poor sleep or insomnia, but the direction of causality between the two is not entirely clear. In this study, we investigated the direction of causality between rumination thinking and sleep quality by constructing a cross-lagged model using a longitudinal study with a two-year interval and explored the possible brain-neurological basis of the association using resting-state functional magnetic resonance imaging(fMRI) data.

Methods:

Participants were 373 current university students (males: n = 84,8.67±0.76 years old) who completed the Ruminative Responses Scale (RRS) and the Pittsburgh Sleep Quality Index (PSQI) at two time points and had resting-state MRI data collected. First, descriptive statistics and Pearson correlation analysis were performed on the questionnaires at each time point, followed by the construction of a cross-lagged model to explore the causal relationship; Then, the precuneus (x=0, y=-53, z=61 mm) was selected as the seed point based on previous literature, and the average correlation coefficient between the precuneus and whole-brain voxels were normalized to z-scores using Fisher's r-to-z transformation(zFC, z-transformed functional connectivity), to further explore the neural basis of the mutual influence of rumination thinking and sleep quality, the bivariate correlation was calculated between three variables (zFC of the precuneus and whole brain, sleep quality, and rumination thinking), and then the mediation analysis was conducted using PROCESS, with gender and FD (frame-wise displacement, a head motion parameter) as covariables. In the mediation modeling process, X was FC, the mediating variable was PSQI or RRS score at time 1, and Y was PSQI or RRS score at time 2.

Results:

The results of the cross-lagged model analysis indicate that sleep quality predicts rumination both concurrently (β=0.34, p<0.001; β=0.17, p<0.01) and across time (β=0.16, p<0.01); similarly, rumination predicts sleep quality both concurrently and across time (β=0.15, p<0.01). We processed partial correlation analysis of the zFC of the precuneus and whole-brain voxels with the scale scores at T1, and the results showed that FC of the precuneus and the lingual gyrus (x=10, y=-88, z=-10) was significantly negatively correlated with RRS_T1 scores (r=-0.251, p<0.001), and not significantly negatively correlated with PSQI_T1 scores (r=-0.089, p=0.112). Considering the cross path of TI rumination thinking affecting T2 sleep quality in the cross-lag model, partial correlation analysis was also conducted between the FC and T2 sleep quality, and the results showed that the FC was significantly negatively correlated with PSQI_T2 scores (r=-0.12, p<0.05). The mediation results showed that T1 rumination plays a fully mediating role between FC of Precuneus-Lingual_R and T2 sleep quality, after regressed out the gender, age and FD, the total effect (c=-2.476, SE=1.147, 95%CI=[-4.7319, -.2202]) and the indirect effect(a×b=-1.753, SE=0.501, 95%CI=[ -2.8318, -.8526]) are significant, and a nonsignificant direct effect (c=0.723, SE=1.121, 95%CI=[-2.9282, 1.4822]).

Conclusions:

rumination thinking and sleep quality are causally related in a bidirectional manner; and the FC of the precuneus and lingual gyrus may be the neural basis for rumination thinking to predict sleep quality.

Modeling and Analysis Methods:

Connectivity (eg. functional, effective, structural) ²

Novel Imaging Acquisition Methods:

BOLD fMRI

Perception, Attention and Motor Behavior:

Sleep and Wakefulness ¹

Keywords:

Other - rumination thinking; sleep quality; rs-fMRI; Longitudinal study

^1|2Indicates the priority used for review

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