Distributed white matter abnormalities in primary trigeminal neuralgia: TBSS study
Poster No:
2357
Submission Type:
Abstract Submission
Authors:
Elena Filimonova1, Anton Pashkov1, Galina Moysak1, Azniv Martirosyan1, Jamil Rzaev1
Institutions:
1Federal Neurosurgical Center, Novosibirsk, Russia
First Author:
Co-Author(s):
Introduction:
Primary trigeminal neuralgia (PTN) is a prevalent chronic pain disorder whose pathogenesis is not limited to the trigeminal system. Despite the significant advances in uncovering underlying mechanisms, there is a paucity of comprehensive and consistent data regarding the role of white matter throughout the entire brain in PTN.
Methods:
Sixty patients with PTN and 28 age- and sex-matched healthy controls were evaluated using diffusion tensor imaging (DTI). A tract-based spatial statistical approach was performed to investigate white matter impairment in patients with PTN with several metrics, including fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). Additionally, ROI-based analysis was performed for each white matter tract to compare FA values between groups with correction for patient age and sex. Correlations between DTI data and nerve root compression severity, as well as pain severity, were also evaluated in patients with PTN.
·Schematic presentation of the DTI postprocessing algorithm
Results:
Our analysis demonstrated a widespread and symmetrical reduction in FA values among TN patients when compared to the control group (p < 0.05). Specifically, this FA decrease was predominantly observed in regions such as the corona radiata, internal capsule, optic radiation, and thalami, as well as structures within the posterior fossa, notably the cerebellar peduncles. No statistically significant differences were found between patients and the control group during the MD, AD and RD map analyses. ROI-based analysis did not reveal statistically significant changes in FA values in white matter tracts (p > 0.05 in all comparisons, FDR-corrected); however, there were trends towards FA value decreases in the internal capsule (p = 0.08, FDR-corrected) and inferior fronto-occipital fasciculus (p = 0.09, FDR-corrected).
·Differences in FA between groups (TBSS results). Green represents the anatomy of white matter tracts.
Conclusions:
Our findings indicate the presence of microstructural abnormalities in white matter among individuals with primary trigeminal neuralgia, which may potentially play a role in the development and progression of the condition.
Neuroanatomy, Physiology, Metabolism and Neurotransmission:
Neuroanatomy Other 2
Novel Imaging Acquisition Methods:
Diffusion MRI 1
Keywords:
MRI
Pain
Tractography
Other - trigeminal neuralgia
1|2Indicates the priority used for review
Provide references using author date format
Kumaran, S., Gurram, S., Viswamitra, S., & Hegde, V. (2022). Utility of DTI (Diffusion Tensor Imaging) Metrics to Study Microstructural Changes of Trigeminal Nerve in Patients with Trigeminal Neuralgia (TN). Neurology India, 70(1), 270–274. https://doi.org/10.4103/0028-3886.338701
Liu, J., Zhu, J., Yuan, F., Zhang, X., & Zhang, Q. (2018). Abnormal brain white matter in patients with right trigeminal neuralgia: a diffusion tensor imaging study. The Journal of Headache and Pain, 19(1). https://doi.org/10.1186/S10194-018-0871-1