Multimodal thalamic features explain the different outcomes in tinnitus patients after sound therapy
Poster No:
2401
Submission Type:
Abstract Submission
Authors:
Qian Chen1, Yan Huang1, Lining Dong1, Zhenchang Wang1
Institutions:
1Beijing Friendship Hospital, Capital Medical University, Beijing, Beijing
First Author:
Co-Author(s):
Introduction:
As the vital station to transform and integrate sensory afferent signals, the thalamus is crucial in tinnitus generation. The contributions of different thalamic subregions to tinnitus and its secondary dysfunction and the underlying mechanisms are undetermined. This study aimed to investigated thalamic structural and functional alterations using multimodal MRI and examined its clinical relevance in tinnitus patients with different outcomes after sound therapy.
Methods:
In total, 60 patients with persistent tinnitus and 57 healthy controls (HCs) were recruited. Based on treatment efficacy, 28 patients were categorized into the effective group and 32 into the ineffective group. Five MRI measurements of the thalamus and its seven subregions, including gray matter volume, fractional anisotropy, fractional amplitude of low-frequency fluctuation, and functional connectivity (FC), were obtained for each participant and compared between the groups.
·The whole analysis method of this study.
Results:
Patients in both the groups exhibited widespread functional and diffusion abnormalities in the whole thalamus and several subregions, with more obvious changes observed in the effective group. All tinnitus patients had abnormal FC compared with the HCs; FC differences between the two patient groups were only observed in the striatal network, auditory-related cortex, and the core area of the limbic system. We combined the multimodal quantitative thalamic alterations and used it as an imaging indicator to evaluate prognosis before sound therapy and achieved a sensitivity of 71.9% and a specificity of 85.7%.
Conclusions:
Similar patterns of thalamic alterations were identified in tinnitus patients with different outcomes, with more obvious changes observed in the effective group. Our findings support the tinnitus generation hypothesis of frontostriatal gating system dysfunction. A combination of multimodal quantitative thalamic properties may be used as indicators to predict tinnitus prognosis before sound therapy.
Novel Imaging Acquisition Methods:
Multi-Modal Imaging 1
Perception, Attention and Motor Behavior:
Perception: Auditory/ Vestibular 2
Keywords:
FUNCTIONAL MRI
Hearing
Limbic Systems
Structures
Thalamus
Therapy
Treatment
White Matter
1|2Indicates the priority used for review
Provide references using author date format
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