Orbitofrontal sulcal patterns in catatonia
Poster No:
509
Submission Type:
Abstract Submission
Authors:
Mylène Moyal1, Alexandre Haroche2, David Attali1, Sylvain Charron3, Clément Debacker3, Boris Chaumette1, Anton Iftimovici1, Alice Le berre1, Matthieu Raoelison4, Ghita Dadi1, Sylvain Leroy1, Catherine Oppenheim2, Arnaud Cachia5, Marion Plaze2
Institutions:
1GHU Paris Psychiatrie et Neurosciences, Paris, Ile de France, 2GHU Paris Psychiatrie et Neurosciences, Paris, France, 3Institut de Psychiatrie et Neurosciences de Paris, Paris, France, 44Université Paris Cité, Laboratory for the Psychology of Child Development and Education, CNRS, Paris, Ile de France, 5LaPsyDé, PARIS, -
First Author:
Co-Author(s):
Matthieu Raoelison
4Université Paris Cité, Laboratory for the Psychology of Child Development and Education, CNRS
Paris, Ile de France
4Université Paris Cité, Laboratory for the Psychology of Child Development and Education, CNRS
Paris, Ile de France
Introduction:
Catatonia is a psychomotor syndrome frequently observed in disorders with neurodevelopmental impairments, including psychiatric disorders such as schizophrenia. The orbitofrontal cortex (OFC) has been repeatedly associated with catatonia including GABAergic deficits during negative emotional processing and poor connectivity with medial prefrontal cortices along with reduced local cortical surface area and increased local gyrification index. The OFC presents with an important inter-individual morphological variability, with three distinct H-shaped sulcal patterns, type I, II, III, based on the continuity of the medial and lateral orbital sulci, see Figure 1. The OFC sulcal pattern are determined in utero, during third semester of gestation and previous studies reported a stability after birth of the sulcal pattern. As opposed to quantitative features of the cortical sheet (e.g., thickness, surface area or curvature) taking decades to reach the levels measured in adult, the qualitative sulcal patterns of the cortex anatomy in postnatal life are a proxy for earlier developmental events. Types II and III sulcal pattern have been identified as neurodevelopmental risk factors for schizophrenia. The sulcal pattern of the OFC has never been investigated in catatonia despite the role of the OFC in the pathophysiology of catatonia and the increasingly documented neurodevelopmental component of catatonia.
Methods:
In this context, we performed a retrospective analysis of the OFC sulcal pattern in carefully selected homogeneous and matched subgroups of schizophrenia and schizo-affective patients with catatonia (N=58) or without catatonia (N=65), and healthy controls (N=82). The classification of OFC sulcal pattern followed the standard visual inspection procedure of Chiavaras and Petrides, based on the continuity of the medial orbital sulcus (MOS) and lateral orbital sulcus (LOS), see figure 1. Classification of the sulcal pattern type was blind to the diagnoses and the sulcal pattern in the contralateral hemisphere by 2 independent raters with 3D slicer sotfware. We added measure of global brain volume, found to be related to the sulcation of the prefrontal cortex to ensure that the difference in sulcal patterns was not related to brain size. Multinomial logistic regressions were used to compare the distribution of OFC sulcal pattern in the left and right hemispheres with group and gender as categorical factor and age as continuous covariate. Post-hoc comparisons, with Tukey correction for multiple tests, were used to investigate distribution differences between pairs of subgroups. This study was authorized by the data protection delegation of the GHU-Paris Psychiatry and Neurosciences under reference number D22-R003.
·OFC sulcal pattern classification. Red sulci= lateral orbital sulcus, blue sulci= medial orbital sulcus, yellow sulci= transverse orbital sulcus, green and purple= intermediate and posterior sulcus
Results:
Logistic regression analyses revealed a group effect on OFC sulcal pattern in the left (χ²=18.1; p<.001) and right (χ²=28.3; p<.001) hemispheres, see Figure 2. Catatonia patients were found to have more type III and less type I in both hemispheres compared to healthy controls and more type III on the left hemisphere compared to schizophrenia patients without catatonia. In addition, the catatonia severity rating scale score was found to be higher in the type III (t ratio=-3.105; p=.02).
·OFC sulcal pattern distribution. Abbreviations: SSD=Schizophrenia; SSD-c=Schizophrenia patients with catatonia; SSD-nc=Schizophrenia patients without catatonia, HC=Healthy Control
Conclusions:
This is the first study to provide evidence of abnormal OFC sulcal patterns in schizophrenia and schizo-affective patients with catatonia, with more type III than in healthy subjects and in patients without catatonia, supporting a neurodevelopmental component of catatonia, at least in schizophrenia and schizo-affective patients. Catatonia neurodevelopmental component is increasingly recognized and needs to be further investigate notably in non-psychosis catatonia patients. Such investigations aim to enhance patient characterization and delve deeper into the underlying pathophysiological mechanisms of catatonia.
Disorders of the Nervous System:
Neurodevelopmental/ Early Life (eg. ADHD, autism)
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 1
Neuroanatomy, Physiology, Metabolism and Neurotransmission:
Cortical Anatomy and Brain Mapping 2
Keywords:
Cortex
Development
DISORDERS
MRI
Psychiatric Disorders
Schizophrenia
Other - catatonia
1|2Indicates the priority used for review
Provide references using author date format
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