Poster No:
1096
Submission Type:
Abstract Submission
Authors:
Leeseul Shim1,2, Ja Hee Kim1,3, Gibbeum Kim1, Hyo-Jeong Lee1,2,3
Institutions:
1Laboratory of Brain & Cognitive Sciences for Convergence Medicine, Hallym University College of Medi, Anyang, Korea, Republic of, 2Ear and Interaction Center, Doheun Institute for Digital Innovation in Medicine (D.I.D.I.M.), Hallym University Medical Center, Anyang, Korea, Republic of, 3Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medici, Chuncheon, Korea, Republic of
First Author:
Leeseul Shim
Laboratory of Brain & Cognitive Sciences for Convergence Medicine, Hallym University College of Medi|Ear and Interaction Center, Doheun Institute for Digital Innovation in Medicine (D.I.D.I.M.), Hallym University Medical Center
Anyang, Korea, Republic of|Anyang, Korea, Republic of
Co-Author(s):
Ja Hee Kim
Laboratory of Brain & Cognitive Sciences for Convergence Medicine, Hallym University College of Medi|Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medici
Anyang, Korea, Republic of|Chuncheon, Korea, Republic of
Gibbeum Kim
Laboratory of Brain & Cognitive Sciences for Convergence Medicine, Hallym University College of Medi
Anyang, Korea, Republic of
Hyo-Jeong Lee
Laboratory of Brain & Cognitive Sciences for Convergence Medicine, Hallym University College of Medi|Ear and Interaction Center, Doheun Institute for Digital Innovation in Medicine (D.I.D.I.M.), Hallym University Medical Center|Department of Otorhinolaryngology-Head and Neck Surgery, Hallym University College of Medici
Anyang, Korea, Republic of|Anyang, Korea, Republic of|Chuncheon, Korea, Republic of
Introduction:
In patients with bilateral deafness, cortical plasticity related to behavioral outcomes has been explored in the auditory/visual sensory domain and the modality-independent cognitive domain. However, neuroplastic change in patients with single-sided deafness (SSD) is still largely unknown and associated with a specific binaural process such as sound localization is scarce. In this fMRI study, neural activity while performing sound localization tasks was explored in patients with single-sided deafness compared to the binaural or monaural hearing controls.
Methods:
A total of 35 patients with severe to profound SSD and 13 normal-hearing controls (NC, n=13, age = 45.2±11.9) participated in the study. The patients with SSD were comprised into two groups: the left SSD (Lt SSD, n=17, age=43.9±15.2) and the right SSD group (Rt SSD, n=18, age=52.6±7.2). All participants performed two fMRI sessions of 14 blocks, each with an auditory localization task. The NC group have conducted the same experiment in three conditions: binaural, right ear-only, and left ear-only. All participants. verbally responded the source direction among the left, front, and right sides. The correct response rate and the RMS error were also acquired during the scan. Imaging analysis was performed using the SPM12 package. Aside from whole-brain analysis of group comparison and correlation, cortical laterality was explored in three auditory ROIs that are cytoarchitectonically defined, accounting for both cluster size and activity strength (WLI: weighted laterality index).
Results:
The NC group in the binaural condition revealed significant activation in the bilateral auditory cortices, regions in the frontal cortex, and the cingulo-opercular network. As expected, the NC group with one ear plugged showed a completely biased response to the side of the open ear. The auditory cortical response is shifted to the hemisphere contralateral to the open ear regardless of the source direction. Similar to the NC group in the binaural state and different from them in monaural conditions, the SSD groups revealed activity in the bilateral STG to all stimuli directions, suggesting that abnormal aural preference has developed in the ipsilateral auditory cortex to the intact ear. Localization-related activity in the right Heschl's gyrus changes as a function of the duration of single-sided deafness, leading to a decreased interhemispheric asymmetry in both SSD groups. In the SSD groups, activity in the posterior STG contralateral to the intact ear and in the cingulo-opercular network was related to the better localization performance in the scanner. Analysis of WLI revealed that a time-related decrease in auditory cortical asymmetry is significant in the earlier auditory areas when the source is in the direction of the impaired ear.
Conclusions:
With an extended duration of the asymmetric hearing, auditory cortical plasticity occurs to respond to the direction of the sound source, regardless of the side of hearing. The functional change seems to occur rapidly in the non-primary areas, while it changes slowly in the core area in a time-varying fashion. The result suggests compensatory neuroplasticity in the dorsal auditory pathway and areas for attentional control is essential to overcome the distorted auditory spatial information for sound localization in patients with SSD.
Learning and Memory:
Neural Plasticity and Recovery of Function 1
Perception, Attention and Motor Behavior:
Perception: Auditory/ Vestibular 2
Keywords:
FUNCTIONAL MRI
Hearing
Plasticity
Other - auditory asymmetry, sound localization
1|2Indicates the priority used for review
Provide references using author date format
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