Childhood Adversity Predicts Striatal Functional Connectivity Gradient Changes After Acute Stress
Poster No:
2018
Submission Type:
Abstract Submission
Authors:
Xiang-Shen Liu1, Koen Haak1, Janna Vrijsen1, Marianne Oldehinkel1, Peter Mulders1, Christian Beckmann1, Guillén Fernández1, Indira Tendolkar1, Nils Kohn1
Institutions:
1Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
First Author:
Xiang-Shen Liu
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Co-Author(s):
Koen Haak
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Janna Vrijsen
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Marianne Oldehinkel
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Peter Mulders
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Christian Beckmann
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Guillén Fernández
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Indira Tendolkar
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Nils Kohn
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour
Nijmegen, The Netherlands
Introduction:
Childhood adversity leads to several maladaptive behavioral and brain changes. One psychopathological consequence of childhood adversity is its impact on individuals' reactivity to acute stress later in life. People with a history of childhood adversity have diminished cardiac and cortisol responses to stress, and this maladaptive change was shown in dpression and other psychiatric disorders. Recent models suggest that the motivational dysregulation may contribute to this blunted stress response (Carroll et al., 2017), which identified the role of striatal network in stress coping behaviors of people with childhood adversity. However, we need more direct evidence on how the striatal connectivity varies under the joint impact of acute stress and childhood adversity, and methods focusing on whole brain connectivity can be highly insightful in providing the overview of this interaction.
The 'connectopic mapping', as an emerging connectivity analysis method, could serve as an ideal tool. This data-driven method was designed to detect several topographic modes (gradients) within the region-of-interest in relation to other regions of the brain (Haak, Marquand, & Beckmann, 2018). Previous studies showed striatal gradients could be an in-vivo readout of the functionality of motivation processing (Marquand, Haak & Beckmann, 2017). Here, we utilized connectopic gradients in the dataset of the 'Measuring Integrated Novel Dimensions in Neurodevelopmental and Stress-related Mental Disorders' study(MIND-Set; van Eijndhoven et al., 2022), to examine if the striatal connectivity gradients change depending on childhood adversity experience, and how acute stress interacts with this pattern.
The 'connectopic mapping', as an emerging connectivity analysis method, could serve as an ideal tool. This data-driven method was designed to detect several topographic modes (gradients) within the region-of-interest in relation to other regions of the brain (Haak, Marquand, & Beckmann, 2018). Previous studies showed striatal gradients could be an in-vivo readout of the functionality of motivation processing (Marquand, Haak & Beckmann, 2017). Here, we utilized connectopic gradients in the dataset of the 'Measuring Integrated Novel Dimensions in Neurodevelopmental and Stress-related Mental Disorders' study(MIND-Set; van Eijndhoven et al., 2022), to examine if the striatal connectivity gradients change depending on childhood adversity experience, and how acute stress interacts with this pattern.
Methods:
In the sample combining 150 psychiatric patients and 26 controls of MIND-Set, we utilized 'connectopic gradients' to capture the functional topographic organizations of striatal connectivity during resting-state scans before and after watching an aversive movie clip (acute stress induction). We focused on the first-order gradient which was previously proven to be associated with goal-directed and motivation behaviors. The trend surface coefficients of connectivity gradients were then linked to the index of childhood adversity (overall index and three subscale scores) by Spearman correlation (p < .05, FDR corrected). Linear mixed models and moderation models were built to clarify the role of symptom strengths in these correlations.
Results:
Participants with different childhood adversity history didn't show significant diverse gradients at the pre-stress resting states, as the connectopic maps could not be predicted by any types of CA (ps > 0.10).
After the stress-induction, this gradient map was related to one type of adversity: the emotional neglect (r = -0.190, p = 0.042). Emotional neglect frequency also negatively predicted the stress reactive change in this connectivity mode (left: r = -0.210, p = 0.033; right: r = -0.230, p = 0.014). By visualizing the gradient maps, we found the first-order gradients of frequently neglected people tend to show a clearer gradual transition from pre-stress rs to post-induction rs.
Linear mixed models and moderation models showed the observed correlations between emotional neglect and striatal gradients only existed in individuals with elevated comorbidity.
After the stress-induction, this gradient map was related to one type of adversity: the emotional neglect (r = -0.190, p = 0.042). Emotional neglect frequency also negatively predicted the stress reactive change in this connectivity mode (left: r = -0.210, p = 0.033; right: r = -0.230, p = 0.014). By visualizing the gradient maps, we found the first-order gradients of frequently neglected people tend to show a clearer gradual transition from pre-stress rs to post-induction rs.
Linear mixed models and moderation models showed the observed correlations between emotional neglect and striatal gradients only existed in individuals with elevated comorbidity.
·Figure 1. The group average of the first-order gradients before and after stress-induction, compared with HCP dataset
·Figure 2. Changes of the first-order gradients from pre-stress to post-stress for frequently emotional neglected participants
Conclusions:
People who experienced frequent emotional neglect displayed distinct stress-induced alterations in the motivation-related connectivity modes. The anterior-posterior organization of striatal gradients could be a new biomarker for the symptomatology of people with frequent neglected history, by tracking stress-related brain changes in the general motivation and high-order cognition systems.
Disorders of the Nervous System:
Psychiatric (eg. Depression, Anxiety, Schizophrenia) 2
Emotion, Motivation and Social Neuroscience:
Emotion and Motivation Other
Modeling and Analysis Methods:
fMRI Connectivity and Network Modeling
Task-Independent and Resting-State Analysis 1
Keywords:
Other - Childhood adversity; Acute stress; Striatum; Connectopic mapping
1|2Indicates the priority used for review
Provide references using author date format
Haak, K. V. (2018), 'Connectopic mapping with resting-state fMRI', Neuroimage, 170, 83-94
McLaughlin, K. A. (2014), 'Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience', Neuroscience & Biobehavioral Reviews, 47, 578-591
Mulders, P. C. (2022), 'Association of striatal connectivity gradients to functional domains across psychiatric disorders', Translational Psychiatry,12, 513
Oldehinkel, M. (2022), 'Mapping dopaminergic projections in the human brain with resting-state fMRI', Elife, 11, e71846
van Eijndhoven, P. F. (2021). 'Measuring integrated novel dimensions in neurodevelopmental and stress-related mental disorders (MIND-Set): a cross-sectional comorbidity study from an RDoC perspective', JMIRx Med, 3(1), e31269