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Dynamic Functional Connectivity of Brain Networks during Acute Stress Regulates Stress Resilience

Poster No:

702 

Submission Type:

Abstract Submission 

Authors:

Juan Yang1

Institutions:

1Southwest University, Chongqing, Chongqing

First Author:

Juan Yang  
Southwest University
Chongqing, Chongqing

Introduction:

Stress resilience has been largely regarded as a process in which individuals actively cope with and recover from stress. Over the past decade, the emergence of large-scale brain networks has provided a new perspective for the study of the neural mechanisms of stress. However, it remains unclear how stress resilience is supported by inter-network functional connectivity (FC) and whether such FCs undergoes time-dependent dynamic changes during stress induction.

Methods:

To bridge this knowledge gap, seventy-seven participants (age, 17–22 years, 37 women) were recruited for a ScanSTRESS brain imaging study. We initially adopt a static perspective, using changes in FC that obtained from stress vs. control condition during the entire stress induction phase as a static indicator. Further, we analyze changes in FC between different stress runs as an index of temporal dynamics. Meanwhile, participants' salivary cortisol levels during stress were collected and analyzed as an index of stress resilience. In addition, participants' trait resilience was measured by the sensitivity of behavioral activation system (BAS).

Results:

We found that, for the static index, enhanced FC between the salience network (SN), default mode network (DMN) and limbic network (LBN) during acute stress could negatively signal stress resilience. For the temporal dynamics index, FC among the dorsal attention network (DAN), central executive network (CEN) and visual network (VN) decreased significantly during repeated stress induction. Moreover, the decline of FC positively signaled a rapid salivary cortisol recovery, and this relationship only exist in people with high BAS.

Conclusions:

In all, this study, for the first time, concurrently investigates the neural mechanisms of stress resilience from both static and dynamic perspectives and elucidates the relationship among dynamic neural activity, stress resilience, and trait resilience within a unified framework.

Emotion, Motivation and Social Neuroscience:

Social Cognition 2
Emotion and Motivation Other 1

Keywords:

Cortex
Emotions
FUNCTIONAL MRI
Limbic Systems
Saliva
Other - stress

1|2Indicates the priority used for review
Supporting Image: FIG1.jpg
   ·Figure 1. Experimental procedure (A), scanning runs (B), stress condition (C) and control condition (D) in the ScanSTRESS paradigm
Supporting Image: FIG3A.jpg
   ·Figure 3 (A) FC of brain networks induced by acute stress (stress vs. control). Depicted lines indicate pairs of ROIs that demonstrate increased FC (red lines) and decreased FC (the blue line) for str
 

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