BRAPH 2.0: A Graph Theory Software for the Analysis of Multilayer Brain Connectivity

The brain is a complex network that relies on the interaction between its various regions, known as the connectome (Sporn 2013). In the past decade, the organization of the human connectome has been studied on different imaging modalities such as structural magnetic resonance imaging (MRI), functional MRI (fMRI), positron emission tomography (PET) and electroencephalogram (EEG) data (Bullmore & Bassett 2011). However, the connectomes obtained from these modalities are often analyzed separately using a single network approach, despite growing evidence that they are not independent and often interact with each other in the same subjects (De Domenico 2017; Mandke et al. 2018).